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Ovarian cancer risk...
Ovarian cancer risk factors by tumor aggressiveness : An analysis from the Ovarian Cancer Cohort Consortium
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Fortner, Renée T. (author)
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Poole, Elizabeth M. (author)
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Wentzensen, Nicolas A. (author)
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Trabert, Britton (author)
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White, Emily (author)
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Arslan, Alan A. (author)
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Patel, Alpa V. (author)
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Setiawan, V. Wendy (author)
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Visvanathan, Kala (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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- Adami, Hans-Olov (author)
- Karolinska Institutet
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Black, Amanda (author)
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Bernstein, Leslie (author)
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Brinton, Louise A. (author)
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Buring, Julie (author)
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Clendenen, Tess V. (author)
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Fournier, Agnès (author)
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Fraser, Gary (author)
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Gapstur, Susan M. (author)
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Gaudet, Mia M. (author)
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Giles, Graham G. (author)
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Gram, Inger T. (author)
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Hartge, Patricia (author)
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Hoffman-Bolton, Judith (author)
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- Idahl, Annika, 1965- (author)
- Umeå universitet,Obstetrik och gynekologi
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Kaaks, Rudolf (author)
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Kirsh, Victoria A. (author)
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Knutsen, Synnove (author)
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Koh, Woon-Puay (author)
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Lacey, James V. (author)
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Lee, I-Min (author)
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- Lundin, Eva (author)
- Umeå universitet,Patologi
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Merritt, Melissa A. (author)
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Milne, Roger L. (author)
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Onland-Moret, N. Charlotte (author)
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Peters, Ulrike (author)
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Poynter, Jenny N. (author)
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Rinaldi, Sabina (author)
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Robien, Kim (author)
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Rohan, Thomas (author)
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Sánchez, Maria-José (author)
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Schairer, Catherine (author)
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Schouten, Leo J. (author)
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Tjonneland, Anne (author)
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Townsend, Mary K. (author)
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Travis, Ruth C. (author)
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Trichopoulou, Antonia (author)
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van den Brandt, Piet A. (author)
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Vineis, Paolo (author)
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Wilkens, Lynne (author)
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- Wolk, Alicja (author)
- Karolinska Institutet
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Yang, Hannah P. (author)
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Zeleniuch-Jacquotte, Anne (author)
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Tworoger, Shelley S. (author)
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(creator_code:org_t)
- 2019-01-14
- 2019
- English.
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 145:1, s. 58-69
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Ovarian cancer risk factors differ by histotype; however, within subtype, there is substantial variability in outcomes. We hypothesized that risk factor profiles may influence tumor aggressiveness, defined by time between diagnosis and death, independent of histology. Among 1.3 million women from 21 prospective cohorts, 4,584 invasive epithelial ovarian cancers were identified and classified as highly aggressive (death in <1 year, n = 864), very aggressive (death in 1 to < 3 years, n = 1,390), moderately aggressive (death in 3 to < 5 years, n = 639), and less aggressive (lived 5+ years, n = 1,691). Using competing risks Cox proportional hazards regression, we assessed heterogeneity of associations by tumor aggressiveness for all cases and among serous and endometrioid/clear cell tumors. Associations between parity (phet = 0.01), family history of ovarian cancer (phet = 0.02), body mass index (BMI; phet ≤ 0.04) and smoking (phet < 0.01) and ovarian cancer risk differed by aggressiveness. A first/single pregnancy, relative to nulliparity, was inversely associated with highly aggressive disease (HR: 0.72; 95% CI [0.58-0.88]), no association was observed for subsequent pregnancies (per pregnancy, 0.97 [0.92-1.02]). In contrast, first and subsequent pregnancies were similarly associated with less aggressive disease (0.87 for both). Family history of ovarian cancer was only associated with risk of less aggressive disease (1.94 [1.47-2.55]). High BMI (≥35 vs. 20 to < 25 kg/m2 , 1.93 [1.46-2.56] and current smoking (vs. never, 1.30 [1.07-1.57]) were associated with increased risk of highly aggressive disease. Results were similar within histotypes. Ovarian cancer risk factors may be directly associated with subtypes defined by tumor aggressiveness, rather than through differential effects on histology. Studies to assess biological pathways are warranted.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- aggressiveness
- ovarian cancer
- prospective cohort
- risk factors
- subtypes
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Fortner, Renée T ...
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Poole, Elizabeth ...
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Wentzensen, Nico ...
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Trabert, Britton
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White, Emily
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Arslan, Alan A.
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show more...
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Patel, Alpa V.
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Setiawan, V. Wen ...
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Visvanathan, Kal ...
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Weiderpass, Elis ...
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Adami, Hans-Olov
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Black, Amanda
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Bernstein, Lesli ...
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Brinton, Louise ...
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Buring, Julie
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Clendenen, Tess ...
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Fournier, Agnès
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Fraser, Gary
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Gapstur, Susan M ...
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Gaudet, Mia M.
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Giles, Graham G.
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Gram, Inger T.
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Hartge, Patricia
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Hoffman-Bolton, ...
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Idahl, Annika, 1 ...
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Kaaks, Rudolf
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Kirsh, Victoria ...
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Knutsen, Synnove
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Koh, Woon-Puay
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Lacey, James V.
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Lee, I-Min
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Lundin, Eva
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Merritt, Melissa ...
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Milne, Roger L.
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Onland-Moret, N. ...
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Peters, Ulrike
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Poynter, Jenny N ...
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Rinaldi, Sabina
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Robien, Kim
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Rohan, Thomas
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Sánchez, Maria-J ...
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Schairer, Cather ...
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Schouten, Leo J.
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Tjonneland, Anne
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Townsend, Mary K ...
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Travis, Ruth C.
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Trichopoulou, An ...
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van den Brandt, ...
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Vineis, Paolo
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Wilkens, Lynne
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Wolk, Alicja
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Yang, Hannah P.
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Zeleniuch-Jacquo ...
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Tworoger, Shelle ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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International Jo ...
- By the university
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Uppsala University
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Umeå University
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Karolinska Institutet