Ovarian cancer risk factors by tumor aggressiveness: An analysis from the Ovarian Cancer Cohort Consortium

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Fortner, Renée T. (author)

Ovarian cancer risk factors by tumor aggressiveness : An analysis from the Ovarian Cancer Cohort Consortium

Article/chapterEnglish2019

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2019-01-14
Wiley,2019
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-419027
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419027URI
https://doi.org/10.1002/ijc.32075DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-159048URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:140827619URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Ovarian cancer risk factors differ by histotype; however, within subtype, there is substantial variability in outcomes. We hypothesized that risk factor profiles may influence tumor aggressiveness, defined by time between diagnosis and death, independent of histology. Among 1.3 million women from 21 prospective cohorts, 4,584 invasive epithelial ovarian cancers were identified and classified as highly aggressive (death in <1 year, n = 864), very aggressive (death in 1 to < 3 years, n = 1,390), moderately aggressive (death in 3 to < 5 years, n = 639), and less aggressive (lived 5+ years, n = 1,691). Using competing risks Cox proportional hazards regression, we assessed heterogeneity of associations by tumor aggressiveness for all cases and among serous and endometrioid/clear cell tumors. Associations between parity (phet = 0.01), family history of ovarian cancer (phet = 0.02), body mass index (BMI; phet ≤ 0.04) and smoking (phet < 0.01) and ovarian cancer risk differed by aggressiveness. A first/single pregnancy, relative to nulliparity, was inversely associated with highly aggressive disease (HR: 0.72; 95% CI [0.58-0.88]), no association was observed for subsequent pregnancies (per pregnancy, 0.97 [0.92-1.02]). In contrast, first and subsequent pregnancies were similarly associated with less aggressive disease (0.87 for both). Family history of ovarian cancer was only associated with risk of less aggressive disease (1.94 [1.47-2.55]). High BMI (≥35 vs. 20 to < 25 kg/m2 , 1.93 [1.46-2.56] and current smoking (vs. never, 1.30 [1.07-1.57]) were associated with increased risk of highly aggressive disease. Results were similar within histotypes. Ovarian cancer risk factors may be directly associated with subtypes defined by tumor aggressiveness, rather than through differential effects on histology. Studies to assess biological pathways are warranted.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
aggressiveness
ovarian cancer
prospective cohort
risk factors
subtypes

Added entries (persons, corporate bodies, meetings, titles ...)

Poole, Elizabeth M. (author)
Wentzensen, Nicolas A. (author)
Trabert, Britton (author)
White, Emily (author)
Arslan, Alan A. (author)
Patel, Alpa V. (author)
Setiawan, V. Wendy (author)
Visvanathan, Kala (author)
Weiderpass, ElisabeteKarolinska Institutet (author)
Adami, Hans-OlovKarolinska Institutet (author)
Black, Amanda (author)
Bernstein, Leslie (author)
Brinton, Louise A. (author)
Buring, Julie (author)
Clendenen, Tess V. (author)
Fournier, Agnès (author)
Fraser, Gary (author)
Gapstur, Susan M. (author)
Gaudet, Mia M. (author)
Giles, Graham G. (author)
Gram, Inger T. (author)
Hartge, Patricia (author)
Hoffman-Bolton, Judith (author)
Idahl, Annika,1965-Umeå universitet,Obstetrik och gynekologi(Swepub:umu)anid0002 (author)
Kaaks, Rudolf (author)
Kirsh, Victoria A. (author)
Knutsen, Synnove (author)
Koh, Woon-Puay (author)
Lacey, James V. (author)
Lee, I-Min (author)
Lundin, EvaUmeå universitet,Patologi(Swepub:umu)evlu0001 (author)
Merritt, Melissa A. (author)
Milne, Roger L. (author)
Onland-Moret, N. Charlotte (author)
Peters, Ulrike (author)
Poynter, Jenny N. (author)
Rinaldi, Sabina (author)
Robien, Kim (author)
Rohan, Thomas (author)
Sánchez, Maria-José (author)
Schairer, Catherine (author)
Schouten, Leo J. (author)
Tjonneland, Anne (author)
Townsend, Mary K. (author)
Travis, Ruth C. (author)
Trichopoulou, Antonia (author)
van den Brandt, Piet A. (author)
Vineis, Paolo (author)
Wilkens, Lynne (author)
Wolk, AlicjaKarolinska Institutet (author)
Yang, Hannah P. (author)
Zeleniuch-Jacquotte, Anne (author)
Tworoger, Shelley S. (author)
Karolinska InstitutetObstetrik och gynekologi (creator_code:org_t)

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In:International Journal of Cancer: Wiley145:1, s. 58-690020-71361097-0215

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By the author/editor: Fortner, Renée T ...; Poole, Elizabeth ...; Wentzensen, Nico ...; Trabert, Britton; White, Emily; Arslan, Alan A.; show more...; Patel, Alpa V.; Setiawan, V. Wen ...; Visvanathan, Kal ...; Weiderpass, Elis ...; Adami, Hans-Olov; Black, Amanda; Bernstein, Lesli ...; Brinton, Louise ...; Buring, Julie; Clendenen, Tess ...; Fournier, Agnès; Fraser, Gary; Gapstur, Susan M ...; Gaudet, Mia M.; Giles, Graham G.; Gram, Inger T.; Hartge, Patricia; Hoffman-Bolton, ...; Idahl, Annika, 1 ...; Kaaks, Rudolf; Kirsh, Victoria ...; Knutsen, Synnove; Koh, Woon-Puay; Lacey, James V.; Lee, I-Min; Lundin, Eva; Merritt, Melissa ...; Milne, Roger L.; Onland-Moret, N. ...; Peters, Ulrike; Poynter, Jenny N ...; Rinaldi, Sabina; Robien, Kim; Rohan, Thomas; Sánchez, Maria-J ...; Schairer, Cather ...; Schouten, Leo J.; Tjonneland, Anne; Townsend, Mary K ...; Travis, Ruth C.; Trichopoulou, An ...; van den Brandt, ...; Vineis, Paolo; Wilkens, Lynne; Wolk, Alicja; Yang, Hannah P.; Zeleniuch-Jacquo ...; Tworoger, Shelle ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

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