Fruit and vegetable consumption and all-cause mortality: a dose-response analysis.

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Bellavia, AndreaKarolinska Institutet (author)

Fruit and vegetable consumption and all-cause mortality : a dose-response analysis.

Article/chapterEnglish2013

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Elsevier BV,2013
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LIBRIS-ID:oai:DiVA.org:uu-419443
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419443URI
https://doi.org/10.3945/ajcn.112.056119DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:127142411URI

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Language:English
Summary in:English

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BACKGROUND: The association between fruit and vegetable (FV) consumption and overall mortality has seldom been investigated in large cohort studies. Findings from the few available studies are inconsistent.OBJECTIVE: The objective was to examine the dose-response relation between FV consumption and mortality, in terms of both time and rate, in a large prospective cohort of Swedish men and women.DESIGN: FV consumption was assessed through a self-administrated questionnaire in a population-based cohort of 71,706 participants (38,221 men and 33,485 women) aged 45-83 y. We performed a dose-response analysis to evaluate 10th survival percentile differences (PDs) by using Laplace regression and estimated HRs by using Cox regression.RESULTS: During 13 y of follow-up, 11,439 deaths (6803 men and 4636 women) occurred in the cohort. In comparison with 5 servings FV/d, a lower consumption was progressively associated with shorter survival and higher mortality rates. Those who never consumed FV lived 3 y shorter (PD: -37 mo; 95% CI: -58, -16 mo) and had a 53% higher mortality rate (HR: 1.53; 95% CI: 1.19, 1.99) than did those who consumed 5 servings FV/d. Consideration of fruit and vegetables separately showed that those who never consumed fruit lived 19 mo shorter (PD: -19 mo; 95% CI: -29, -10 mo) than did those who ate 1 fruit/d. Participants who consumed 3 vegetables/d lived 32 mo longer than did those who never consumed vegetables (PD: 32 mo; 96% CI: 13, 51 mo).CONCLUSION: FV consumption <5 servings/d is associated with progressively shorter survival and higher mortality rates. The Swedish Mammography Cohort and the Cohort of Swedish Men were registered at clinicaltrials.gov as NCT01127698 and NCT01127711, respectively.

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Larsson, Susanna CKarolinska Institutet,Uppsala universitet,Ortopedi (author)
Bottai, MatteoKarolinska Institutet (author)
Wolk, AlicjaKarolinska Institutet,Uppsala universitet,Ortopedi(Swepub:uu)alwol516 (author)
Orsini, NicolaKarolinska Institutet (author)
Karolinska InstitutetOrtopedi (creator_code:org_t)

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In:American Journal of Clinical Nutrition: Elsevier BV98:2, s. 454-4590002-91651938-3207

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By the author/editor: Bellavia, Andrea; Larsson, Susanna ...; Bottai, Matteo; Wolk, Alicja; Orsini, Nicola

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Nutrition and Di ...

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