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A practical guide t...
A practical guide to microfabrication and patterning of hydrogels for biomimetic cell culture scaffolds
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- Tenje, Maria (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Mikrosystemteknik,EMBLA
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- Cantoni, Federico (author)
- Uppsala universitet,Mikrosystemteknik,Science for Life Laboratory, SciLifeLab,EMBLA
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- Porras, Ana Maria (author)
- Uppsala universitet,Mikrosystemteknik,Science for Life Laboratory, SciLifeLab,EMBLA
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- Searle, Sean S., 1991- (author)
- Uppsala universitet,Mikrosystemteknik,Science for Life Laboratory, SciLifeLab,Dept. Biomedical Engineering, National University of Singapore, Singapore,EMBLA
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- Johansson, Sofia (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Mikrosystemteknik,EMBLA
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- Barbe, Laurent (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Mikrosystemteknik,EMBLA
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- Antfolk, Maria (author)
- Biotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen. Also Novo Nordisk Foundation Center for Stem Cell Research, Faculty of Health and Medical Sciences, University of Copenhagen
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- Pohlit, Hannah (author)
- Uppsala universitet,Mikrosystemteknik,Science for Life Laboratory, SciLifeLab,EMBLA
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(creator_code:org_t)
- The Netherlands : Elsevier, 2020
- 2020
- English.
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In: Organs-on-a-Chip. - The Netherlands : Elsevier. - 2666-1020. ; 2
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Abstract
Subject headings
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- This review article describes microfabrication techniques to define chemical, mechanical and structural patterns in hydrogels and how these can be used to prepare in vivo like, i.e. biomimetic, cell culture scaffolds. Hydrogels are attractive materials for 3D cell cultures as they provide ideal culture conditions and they are becoming more prominently used. Single material gels without any modifications do however have their limitation in use and much can be gained by in improving the in vivo resemblance of simple hydrogel cell culture scaffolds. This review article discusses the most commonly used cross-linking strategies used for hydrogel-based culture scaffolds and gives a brief introduction to microfabrication methods that can be used to define chemical, mechanical and structural patterns in hydrogels with micrometre resolution. The review article also describes a selection of literature references using these microfabrication techniques to prepare organ and disease models with controlled cell adhesion, proliferation and migration. It is intended to serve as an introduction to microfabrication of hydrogels and an inspiration for novel interdisciplinary research projects.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
Keyword
- Microfabrication
- Hydrogels
- 3D cell cultures
- Organs-on-chip
- Microfluidics
- Teknisk fysik med inriktning mot mikrosystemteknik
- Engineering Science with specialization in Microsystems Technology
Publication and Content Type
- ref (subject category)
- for (subject category)
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