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Multi-Fetal Pregnan...
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Bergman, LinaGothenburg University,Göteborgs universitet,Uppsala universitet,Klinisk obstetrik,Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Obstet & Gynecol, Gothenburg, Sweden.,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
(author)
Multi-Fetal Pregnancy, Preeclampsia, and Long-Term Cardiovascular Disease
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-419940
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419940URI
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https://doi.org/10.1161/HYPERTENSIONAHA.120.14860DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:144130607URI
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https://gup.ub.gu.se/publication/299301URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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This Swedish register-based cohort study determined the separate and joint contribution of preeclampsia and multi-fetal pregnancy on a woman's risk of cardiovascular disease (CVD) later in life. The study included 892 425 first deliveries between 1973 and 2010 of women born 1950 until 1971, identified in the Swedish Medical Birth Register. A composite outcome of CVD was retrieved through linkage with the National Patient and Cause of Death Registers. Cox proportional hazard regression was used to assess the risk of CVD in women who had preeclampsia in a singleton or multi-fetal pregnancy, adjusting for potential confounders, and presented as adjusted hazard ratios. Compared with women who had a singleton pregnancy without preeclampsia (the referent group), women with preeclampsia in a singleton pregnancy had an increased risk of CVD (adjusted hazard ratio 1.75 [95% CI, 1.64-1.86]). Women who had a multi-fetal pregnancy without or with preeclampsia did not have an increased risk of future CVD (adjusted hazard ratios 0.94 [95% CI, 0.79-1.10] and 1.25 [95% CI, 0.83-1.86], respectively). As opposed to preeclampsia in a first singleton pregnancy, preeclampsia in a first multi-fetal pregnancy was not associated with increased risk of future CVD. This may support the theory that preeclampsia in multi-fetal pregnancies more often occurs as a result of the larger pregnancy-related burden on the maternal cardiovascular system and excessive placenta-shed inflammatory factors, rather than the woman's underlying cardiovascular phenotype.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Nordlöf-Callbo, PalizUppsala universitet,Klinisk obstetrik(Swepub:uu)palno442
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Wikström, Anna-Karin,1965-Uppsala universitet,Klinisk obstetrik(Swepub:uu)annwi179
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Snowden, Jonathan M.Portland State Univ, Oregon Hlth & Sci Univ, Sch Publ Hlth, Portland, OR 97207 USA.;Oregon Hlth & Sci Univ, Dept Obstet & Gynecol, Portland, OR 97201 USA.
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Hesselman, Susanne,1973-Uppsala universitet,Klinisk obstetrik,Centrum för klinisk forskning Dalarna(Swepub:uu)sushe649
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Bonamy, Anna-Karin EdstedtKarolinska Institutet
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Sandström, AnnaKarolinska Institutet,Uppsala universitet,Klinisk obstetrik,Oregon Hlth & Sci Univ, Dept Obstet & Gynecol, Portland, OR 97201 USA.;Karolinska Inst, Dept Med, Clin Epidemiol Div, Stockholm, Sweden.(Swepub:uu)annsa238
(author)
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Uppsala universitetKlinisk obstetrik
(creator_code:org_t)
Related titles
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In:Hypertension76:1, s. 167-1750194-911X1524-4563
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