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Deep Phenotyping of...
Deep Phenotyping of Parkinson's Disease
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- Dorsey, E. Ray (author)
- Univ Rochester, Med Ctr, Ctr Hlth Technol, Rochester, NY 14642 USA.;Univ Rochester, Med Ctr, Dept Neurol, Rochester, NY 14642 USA.
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- Omberg, Larsson (author)
- Sage Bionetworks, Seattle, WA USA.
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- Waddell, Emma (author)
- Univ Rochester, Med Ctr, Ctr Hlth Technol, Rochester, NY 14642 USA.
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- Adams, Jamie L. (author)
- Univ Rochester, Med Ctr, Ctr Hlth Technol, Rochester, NY 14642 USA.;Univ Rochester, Med Ctr, Dept Neurol, Rochester, NY 14642 USA.
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- Adams, Roy (author)
- Johns Hopkins Univ, Machine Learning AI & Healthcare Lab, Baltimore, MD USA.
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- Ali, Mohammad Rafayet (author)
- Univ Rochester, Dept Comp Sci, Rochester, NY 14627 USA.
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- Amodeo, Katherine (author)
- Univ Rochester, Med Ctr, Dept Neurol, Rochester, NY 14642 USA.
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- Arky, Abigail (author)
- Univ Rochester, Med Ctr, Ctr Hlth Technol, Rochester, NY 14642 USA.
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- Augustine, Erika F. (author)
- Univ Rochester, Med Ctr, Ctr Hlth Technol, Rochester, NY 14642 USA.;Univ Rochester, Med Ctr, Dept Neurol, Rochester, NY 14642 USA.
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- Dinesh, Karthik (author)
- Univ Rochester, Dept Elect & Comp Sci, Rochester, NY USA.
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- Hoque, Mohammed Ehsan (author)
- Univ Rochester, Dept Comp Sci, Rochester, NY 14627 USA.
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- Glidden, Alistair M. (author)
- Univ Rochester, Med Ctr, Ctr Hlth Technol, Rochester, NY 14642 USA.
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- Jensen-Roberts, Stella (author)
- Univ Rochester, Med Ctr, Ctr Hlth Technol, Rochester, NY 14642 USA.
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- Kabelac, Zachary (author)
- MIT, Dept Comp Sci & Artificial Intelligence, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Katabi, Dina (author)
- MIT, Dept Comp Sci & Artificial Intelligence, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Kieburtz, Karl (author)
- Univ Rochester, Med Ctr, Ctr Hlth Technol, Rochester, NY 14642 USA.;Univ Rochester, Med Ctr, Dept Neurol, Rochester, NY 14642 USA.
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- Kinel, Daniel R. (author)
- Univ Rochester, Med Ctr, Ctr Hlth Technol, Rochester, NY 14642 USA.;Univ Rochester, Med Ctr, Dept Neurol, Rochester, NY 14642 USA.
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- Little, Max A. (author)
- Univ Birmingham, Sch Comp Sci, Birmingham, W Midlands, England.;MIT, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Lizarraga, Karlo J. (author)
- Univ Rochester, Med Ctr, Ctr Hlth Technol, Rochester, NY 14642 USA.;Univ Rochester, Med Ctr, Dept Neurol, Rochester, NY 14642 USA.
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- Myers, Taylor (author)
- Univ Rochester, Med Ctr, Ctr Hlth Technol, Rochester, NY 14642 USA.
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- Riggare, Sara (author)
- Karolinska Institutet,Uppsala universitet,Klinisk psykologi i hälso- och sjukvård
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- Rosero, Spencer Z. (author)
- Univ Rochester, Dept Med, Rochester, NY USA.
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- Saria, Suchi (author)
- Johns Hopkins Univ, Machine Learning AI & Healthcare Lab, Baltimore, MD USA.;Johns Hopkins Univ, Dept Comp Sci Stat & Hlth Policy, Baltimore, MD USA.
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- Schifitto, Giovanni (author)
- Univ Rochester, Med Ctr, Dept Neurol, Rochester, NY 14642 USA.
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- Schneider, Ruth B. (author)
- Univ Rochester, Med Ctr, Ctr Hlth Technol, Rochester, NY 14642 USA.;Univ Rochester, Med Ctr, Dept Neurol, Rochester, NY 14642 USA.
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- Sharma, Gaurav (author)
- Univ Rochester, Dept Elect & Comp Sci, Rochester, NY USA.;Univ Rochester, Med Ctr, Dept Biostat & Computat Biol, Rochester, NY 14642 USA.
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- Shoulson, Ira (author)
- Univ Rochester, Med Ctr, Ctr Hlth Technol, Rochester, NY 14642 USA.;Univ Rochester, Med Ctr, Dept Neurol, Rochester, NY 14642 USA.;Grey Matter Technol, Sarasota, FL USA.
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- Stevenson, E. Anna (author)
- Univ Rochester, Med Ctr, Ctr Hlth Technol, Rochester, NY 14642 USA.
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- Tarolli, Christopher G. (author)
- Univ Rochester, Med Ctr, Ctr Hlth Technol, Rochester, NY 14642 USA.;Univ Rochester, Med Ctr, Dept Neurol, Rochester, NY 14642 USA.
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- Luo, Jiebo (author)
- Univ Rochester, Dept Comp Sci, Rochester, NY 14627 USA.
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- McDermott, Michael P. (author)
- Univ Rochester, Med Ctr, Ctr Hlth Technol, Rochester, NY 14642 USA.;Univ Rochester, Med Ctr, Dept Biostat & Computat Biol, Rochester, NY 14642 USA.
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Univ Rochester, Med Ctr, Ctr Hlth Technol, Rochester, NY 14642 USA;Univ Rochester, Med Ctr, Dept Neurol, Rochester, NY 14642 USA. Sage Bionetworks, Seattle, WA USA. (creator_code:org_t)
- IOS Press, 2020
- 2020
- English.
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In: Journal of Parkinson's Disease. - : IOS Press. - 1877-7171 .- 1877-718X. ; 10:3, s. 855-873
- Related links:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Subject headings
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- Phenotype is the set of observable traits of an organism or condition. While advances in genetics, imaging, and molecular biology have improved our understanding of the underlying biology of Parkinson's disease (PD), clinical pheno-typing of PD still relies primarily on history and physical examination. These subjective, episodic, categorical assessments are valuable for diagnosis and care but have left gaps in our understanding of the PD phenotype. Sensors can provide objective, continuous, real-world data about the PD clinical phenotype, increase our knowledge of its pathology, enhance evaluation of therapies, and ultimately, improve patient care. In this paper, we explore the concept of deep phenotyping-the comprehensive assessment of a condition using multiple clinical, biological, genetic, imaging, and sensor-based tools-for PD. We discuss the rationale for, outline current approaches to, identify benefits and limitations of, and consider future directions for deep clinical phenotyping.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Autonomic nervous system
- gait
- natural history
- observational study
- Parkinson's disease
- phenotype
- real-world data
- sleep
- smartphone
- social behavior
Publication and Content Type
- ref (subject category)
- for (subject category)
Find in a library
To the university's database
- By the author/editor
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Dorsey, E. Ray
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Omberg, Larsson
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Waddell, Emma
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Adams, Jamie L.
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Adams, Roy
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Ali, Mohammad Ra ...
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show more...
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Amodeo, Katherin ...
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Arky, Abigail
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Augustine, Erika ...
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Dinesh, Karthik
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Hoque, Mohammed ...
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Glidden, Alistai ...
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Jensen-Roberts, ...
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Kabelac, Zachary
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Katabi, Dina
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Kieburtz, Karl
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Kinel, Daniel R.
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Little, Max A.
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Lizarraga, Karlo ...
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Myers, Taylor
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Riggare, Sara
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Rosero, Spencer ...
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Saria, Suchi
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Schifitto, Giova ...
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Schneider, Ruth ...
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Sharma, Gaurav
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Shoulson, Ira
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Stevenson, E. An ...
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Tarolli, Christo ...
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Luo, Jiebo
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McDermott, Micha ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Journal of Parki ...
- By the university
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Uppsala University
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Karolinska Institutet