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Plasma proteome pro...
Plasma proteome profiling of cardiotoxicity in patients with diffuse large B-cell lymphoma
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- Mörth, Charlott (author)
- Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Experimentell och klinisk onkologi,Gunilla Enblad
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- Sabaa, Amal Abu (author)
- Uppsala universitet,Experimentell och klinisk onkologi,Center for Research and Development, Uppsala University/Region Gävleborg, Uppsala, Sweden
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- Freyhult, Eva, 1979- (author)
- Uppsala universitet,Cancerfarmakologi och beräkningsmedicin,Science for Life Laboratory, SciLifeLab,National Bioinformatics Infrastructure Sweden
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- Christersson, Christina (author)
- Uppsala universitet,Kardiologi
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- Hashemi, Jamileh (author)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Hashemi, Nashmil (author)
- Department of Cardiology, Danderyd hospital, Karolinska Institute, Stockholm Sweden
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- Kamali-Moghaddam, Masood (author)
- Uppsala universitet,Molekylära verktyg,Science for Life Laboratory, SciLifeLab
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- Molin, Daniel, 1969- (author)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Höglund, Martin (author)
- Uppsala universitet,Hematologi
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- Eriksson, Anna, 1977- (author)
- Uppsala universitet,Hematologi
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- Enblad, Gunilla (author)
- Uppsala universitet,Experimentell och klinisk onkologi
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(creator_code:org_t)
- 2021-02-03
- 2021
- English.
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In: Cardio-Oncology. - : Springer Science and Business Media LLC. - 2057-3804. ; 7:1
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Abstract
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- Background Cardiovascular toxicity is a notorious complication of doxorubicin (DXR) therapy for diffuse large B-cell lymphoma (DLBCL). Although surveillance of well-known biological markers for cardiovascular disease (CVD) as NTproBNP and Troponins may be helpful, there are no established markers to monitor for evolving CVD during treatment. New possibilities have arisen with the emergence of newer techniques allowing for analysis of plasma proteins that can be associated with cardiovascular disease. Proximity Extension Assay is one of them. Objectives We aimed to illustrate the incidence of CVD in DLBCL patients treated with DXR and to establish whether there are plasma proteins associated with pre-existing or emerging CVD. Methods In 95 patients, 182 different proteins from OLINK panels, NTproBNP, Troponin I and CRP were assessed prior to, during and after treatment. For comparison, samples from controls were analyzed. Results In the DLBCL cohort, 33.3% had pre-treatment CVD compared to 5.0% in the controls and 23.2% developed new CVD. Of the 32.6% who died during follow up, CVD was the cause in 4 patients. Spondin-1 (SPON-1) correlated to pre-treatment CVD (1.22 fold change, 95% CI 1.10-1.35, p = 0.00025, q = 0.045). Interleukin-1 receptor type 1 (IL-1RT1) was associated to emerging CVD (1.24 fold change, 95% CI 1.10-1.39, p = 0.00044, q = 0.082). Conclusion We observed a higher prevalence of CVD in DLBCL patients compared to controls prior to DXR therapy. Two proteins, SPON-1 and IL-1RT1, were related to pre-existing and emerging CVD in DXR treated patients. If confirmed in larger cohorts, IL-1RT1 may emerge as a reliable biomarker for unfolding CVD in DLBCL.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- By the author/editor
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Mörth, Charlott
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Sabaa, Amal Abu
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Freyhult, Eva, 1 ...
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Christersson, Ch ...
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Hashemi, Jamileh
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Hashemi, Nashmil
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Kamali-Moghaddam ...
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Molin, Daniel, 1 ...
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Höglund, Martin
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Eriksson, Anna, ...
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Enblad, Gunilla
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cardio-Oncology
- By the university
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Uppsala University