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Acquired Functional...
Acquired Functional Capsid Structures in Metazoan Totivirus-like dsRNA Virus
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- Okamoto, Kenta (author)
- Uppsala universitet,Molekylär biofysik
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- Ferreira, Ricardo J., PhD, 1980- (author)
- Uppsala universitet,Molekylär biofysik,Science for Life Laboratory, SciLifeLab
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- Larsson, Daniel S D (author)
- Uppsala universitet,Molekylär biofysik
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- Maia, Filipe R.N.C. (author)
- Uppsala universitet,Molekylär biofysik
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- Isawa, Haruhiko (author)
- Natl Inst Infect Dis NIID, Dept Med Entomol, Tokyo, Japan.
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- Sawabe, Kyoko (author)
- Natl Inst Infect Dis NIID, Dept Med Entomol, Tokyo, Japan.
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- Murata, Kazuyoshi (author)
- Natl Inst Physiol Sci NIPS, Okazaki, Aichi, Japan.
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- Hajdu, Janos (author)
- Uppsala universitet,Molekylär biofysik,Inst Phys AS CR, Vvi, ELI Beamlines, Na Slovance 2, Prague 18221 8, Czech Republic.
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- Iwasaki, Kenji (author)
- Osaka Univ, Inst Prot Res, Lab Prot Synth & Express, Suita, Osaka, Japan.;Univ Tsukuba, Tsukuba Adv Res Alliance TARA, Life Sci Ctr Survival Dynam, Tsukuba, Ibaraki, Japan.
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- Kasson, Peter M. (author)
- Uppsala universitet,Molekylär biofysik
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- Miyazaki, Naoyuki (author)
- Osaka Univ, Inst Prot Res, Lab Prot Synth & Express, Suita, Osaka, Japan.;Univ Tsukuba, Tsukuba Adv Res Alliance TARA, Life Sci Ctr Survival Dynam, Tsukuba, Ibaraki, Japan.
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English.
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In: Structure. - : Elsevier BV. - 0969-2126 .- 1878-4186. ; 28:8, s. 888-
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https://doi.org/10.1...
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Abstract
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- Non-enveloped icosahedral double-stranded RNA (dsRNA) viruses possess multifunctional capsids required for their proliferation. Whereas protozoan/fungal dsRNA viruses have a relatively simple capsid structure, which suffices for the intracellular phase in their life cycle, metazoan dsRNA viruses have acquired additional structural features as an adaptation for extracellular cell-to-cell transmission in multicellular hosts. Here, we present the first atomic model of a metazoan dsRNA totivirus-like virus and the structure reveals three unique structural traits: a C-terminal interlocking arm, surface projecting loops, and an obstruction at the pore on the 5-fold symmetry axis. These traits are keys to understanding the capsid functions of metazoan dsRNA viruses, such as particle stability and formation, cell entry, and endogenous intraparticle transcription of mRNA. On the basis of molecular dynamics simulations of the obstructed pore, we propose a possible mechanism of intraparticle transcription in totivirus-like viruses, which dynamically switches between open and closed states of the pore(s).
Subject headings
- NATURVETENSKAP -- Biologi -- Strukturbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Structural Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Structure
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- By the author/editor
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Okamoto, Kenta
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Ferreira, Ricard ...
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Larsson, Daniel ...
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Maia, Filipe R.N ...
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Isawa, Haruhiko
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Sawabe, Kyoko
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Murata, Kazuyosh ...
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Hajdu, Janos
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Iwasaki, Kenji
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Kasson, Peter M.
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Miyazaki, Naoyuk ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Structural Biolo ...
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Structure
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Uppsala University