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Clinicopathological...
Clinicopathological features and prognostic value of SOX11 in childhood acute lymphoblastic leukemia
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- Gronroos, Toni (author)
- Tampere Univ, Fac Med & Hlth Technol, Tampere Ctr Child Hlth Res, Tampere, Finland.
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- Makinen, Artturi (author)
- Tampere Univ, Fac Med & Hlth Technol, Tampere Ctr Child Hlth Res, Tampere, Finland.;Tampere Univ Hosp, Dept Pathol, Fimlab Labs, Tampere, Finland.
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- Laukkanen, Saara (author)
- Tampere Univ, Fac Med & Hlth Technol, Tampere Ctr Child Hlth Res, Tampere, Finland.
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- Mehtonen, Juha (author)
- Univ Eastern Finland, Inst Biomed, Sch Med, Kuopio, Finland.
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- Nikkila, Atte (author)
- Tampere Univ, Fac Med & Hlth Technol, Tampere Ctr Child Hlth Res, Tampere, Finland.
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- Oksa, Laura (author)
- Tampere Univ, Fac Med & Hlth Technol, Tampere Ctr Child Hlth Res, Tampere, Finland.
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- Rounioja, Samuli (author)
- Tampere Univ Hosp, Dept Hematol, Fimlab Labs, Tampere, Finland.
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- Marincevic-Zuniga, Yanara (author)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
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- Nordlund, Jessica (author)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
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- Pohjolainen, Virva (author)
- Tampere Univ Hosp, Dept Pathol, Fimlab Labs, Tampere, Finland.
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- Paavonen, Timo (author)
- Tampere Univ Hosp, Dept Pathol, Fimlab Labs, Tampere, Finland.;Tampere Univ, Fac Med & Hlth Technol, Dept Pathol, Tampere, Finland.
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Heinaniemi, Merja (author)
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- Lohi, Olli (author)
- Tampere Univ, Fac Med & Hlth Technol, Tampere Ctr Child Hlth Res, Tampere, Finland.;Tampere Univ Hosp, Dept Pediat, Tampere, Finland.
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Tampere Univ, Fac Med & Hlth Technol, Tampere Ctr Child Hlth Res, Tampere, Finland Tampere Univ, Fac Med & Hlth Technol, Tampere Ctr Child Hlth Res, Tampere, Finland.;Tampere Univ Hosp, Dept Pathol, Fimlab Labs, Tampere, Finland. (creator_code:org_t)
- 2020-02-06
- 2020
- English.
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In: Scientific Reports. - : NATURE PUBLISHING GROUP. - 2045-2322. ; 10:1
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Abstract
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- Acute lymphoblastic leukemia is marked by aberrant transcriptional features that alter cell differentiation, self-renewal, and proliferative features. We sought to identify the transcription factors exhibiting altered and subtype-specific expression patterns in B-ALL and report here that SOX11, a developmental and neuronal transcription factor, is aberrantly expressed in the ETV6-RUNX1 and TCF3-PBX1 subtypes of acute B-cell leukemias. We show that a high expression of SOX11 leads to alterations of gene expression that are typically associated with cell adhesion, migration, and differentiation. A high expression is associated with DNA hypomethylation at the SOX11 locus and a favorable outcome. The results indicate that SOX11 expression marks a group of patients with good outcomes and thereby prompts further study of its use as a biomarker.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Gronroos, Toni
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Makinen, Artturi
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Laukkanen, Saara
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Mehtonen, Juha
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Nikkila, Atte
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Oksa, Laura
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show more...
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Rounioja, Samuli
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Marincevic-Zunig ...
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Nordlund, Jessic ...
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Pohjolainen, Vir ...
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Paavonen, Timo
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Heinaniemi, Merj ...
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Lohi, Olli
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Scientific Repor ...
- By the university
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Uppsala University