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Antibodies to citru...
Antibodies to citrullinated peptides in serum and saliva in patients with rheumatoid arthritis and their association to periodontitis
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- Svärd, Anna (författare)
- Uppsala University,Uppsala universitet,Centrum för klinisk forskning Dalarna,Uppsala University, SWE
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- Renvert, Stefan (författare)
- Kristianstad University,University of Kristianstad, SWE,Oral Health - Public Health - Quality of Life (OHAL),Department of Oral Health,Oral Hälsa - Allmänhälsa - Livskvalitet (OHAL),Avdelningen för oral hälsa
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- Sanmartin Berglund, Johan, Professor (författare)
- Blekinge Tekniska Högskola,Blekinge Institute of Technology,Institutionen för hälsa
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- Persson, R. G. (författare)
- Kristianstad University,Kristianstad University, SWE,Oral Health - Public Health - Quality of Life (OHAL),Department of Oral Health,Oral Hälsa - Allmänhälsa - Livskvalitet (OHAL),Avdelningen för oral hälsa
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- Söderlin, Maria (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, SWE
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- CLINICAL & EXPER RHEUMATOLOGY, 2020
- 2020
- Engelska.
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Ingår i: Clinical and Experimental Rheumatology. - : CLINICAL & EXPER RHEUMATOLOGY. - 0392-856X .- 1593-098X. ; 38:4, s. 699-704
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Abstract
Ämnesord
Stäng
- Objectives A connection between prevalence of rheumatoid arthritis (RA) and periodontitis has been reported. The hypothesis for this association involves increased citrullination in the oral mucosa in patients with periodontitis. Whether ongoing periodontitis has an effect on IgA antibodies to citrullinated peptides (ACPA) in saliva is unknown. We studied IgA ACPA in saliva and serum and their relation to periodontitis and smoking in a population-based elderly RA cohort. Methods A population-based cohort of patients with RA >= 61 years of age (n=132) was examined by rheumatologists and a dental hygienist. Analyses of IgG ACPA in serum and IgA ACPA in serum and saliva were performed. The presence of ACPA was compared in patients with RA with and without periodontitis. Results IgA ACPA in serum occurred in 35% of RA patients with periodontitis and in 43% of RA patients without periodontitis (p=0.740). IgG ACPA in serum was found in 66% of RA patients with periodontitis, and in 69% without periodontitis (p=0.740). IgA ACPA in saliva occurred in 20% with periodontitis and 55% without periodontitis (p=0.062). A logistic regression analysis adjusting for age, gender and smoking gave an odds ratio (OR) of 0.456 (95% CI=0.183-1.137, p=0.092) for saliva IgA ACPA positive individuals to have periodontitis. Conclusions IgA ACPA in serum or saliva was not more common in RA patients with periodontitis. This implies that local production of ACPA by the oral mucosa is not enhanced by periodontal inflammation, in patients with established RA.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- rheumatoid arthritis
- periodontitis
- epidemiology
- smoking
- anti-citrullinated peptide antibodies
- Anti-citrullinated peptide antibodies
- Epidemiology
- Periodontitis
- Rheumatoid arthritis
- Smoking
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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