Search: onr:"swepub:oai:DiVA.org:uu-420893" > Fatty acids in the ...
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000 | 11041naa a2200937 4500 | |
001 | oai:DiVA.org:uu-420893 | |
003 | SwePub | |
008 | 201002s2020 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4208932 URI |
024 | 7 | a https://doi.org/10.1371/journal.pmed.10031022 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Imamura, Fumiakiu Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.4 aut |
245 | 1 0 | a Fatty acids in the de novo lipogenesis pathway and incidence of type 2 diabetes :b A pooled analysis of prospective cohort studies |
264 | c 2020-06-12 | |
264 | 1 | b Public Library of Science (PLoS),c 2020 |
338 | a electronic2 rdacarrier | |
520 | a BackgroundDe novo lipogenesis (DNL) is the primary metabolic pathway synthesizing fatty acids from carbohydrates, protein, or alcohol. Our aim was to examine associations of in vivo levels of selected fatty acids (16:0, 16:1n7, 18:0, 18:1n9) in DNL with incidence of type 2 diabetes (T2D).Methods and findingsSeventeen cohorts from 12 countries (7 from Europe, 7 from the United States, 1 from Australia, 1 from Taiwan; baseline years = 1970–1973 to 2006–2010) conducted harmonized individual-level analyses of associations of DNL-related fatty acids with incident T2D. In total, we evaluated 65,225 participants (mean ages = 52.3–75.5 years; % women = 20.4%–62.3% in 12 cohorts recruiting both sexes) and 15,383 incident cases of T2D over the 9-year follow-up on average. Cohort-specific association of each of 16:0, 16:1n7, 18:0, and 18:1n9 with incident T2D was estimated, adjusted for demographic factors, socioeconomic characteristics, alcohol, smoking, physical activity, dyslipidemia, hypertension, menopausal status, and adiposity. Cohort-specific associations were meta-analyzed with an inverse-variance-weighted approach. Each of the 4 fatty acids positively related to incident T2D. Relative risks (RRs) per cohort-specific range between midpoints of the top and bottom quintiles of fatty acid concentrations were 1.53 (1.41–1.66; p < 0.001) for 16:0, 1.40 (1.33–1.48; p < 0.001) for 16:1n-7, 1.14 (1.05–1.22; p = 0.001) for 18:0, and 1.16 (1.07–1.25; p < 0.001) for 18:1n9. Heterogeneity was seen across cohorts (I2 = 51.1%–73.1% for each fatty acid) but not explained by lipid fractions and global geographical regions. Further adjusted for triglycerides (and 16:0 when appropriate) to evaluate associations independent of overall DNL, the associations remained significant for 16:0, 16:1n7, and 18:0 but were attenuated for 18:1n9 (RR = 1.03, 95% confidence interval (CI) = 0.94–1.13). These findings had limitations in potential reverse causation and residual confounding by imprecisely measured or unmeasured factors.ConclusionsConcentrations of fatty acids in the DNL were positively associated with T2D incidence. Our findings support further work to investigate a possible role of DNL and individual fatty acids in the development of T2D. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
700 | 1 | a Fretts, Amanda M.u Univ Washington, Dept Epidemiol, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA.4 aut |
700 | 1 | a Marklund, Mattiu Uppsala universitet,Klinisk nutrition och metabolism,Univ New South Wales, George Inst Global Hlth, Fac Med, Sydney, NSW, Australia.;Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA.4 aut0 (Swepub:uu)matma701 |
700 | 1 | a Ardisson Korat, Andres V.u Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.4 aut |
700 | 1 | a Yang, Wei-Sinu Natl Taiwan Univ, Inst Epidemiol & Prevent Med, Coll Publ Hlth, Taipei, Taiwan.4 aut |
700 | 1 | a Lankinen, Mariau Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.4 aut |
700 | 1 | a Qureshi, Waqasu Wake Forest Univ, Sch Med, Dept Internal Med, Sect Cardiovasc Med, Winston Salem, NC 27101 USA.4 aut |
700 | 1 | a Helmer, Catherineu Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France.4 aut |
700 | 1 | a Chen, Tzu-Anu USDA ARS, Childrens Nutr Res Ctr, Dept Pediat, Baylor Coll Med, Houston, TX USA.4 aut |
700 | 1 | a Virtanen, Jyrki K.u Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.4 aut |
700 | 1 | a Wong, Kerryu Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.4 aut |
700 | 1 | a Bassett, Julie K.u Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.4 aut |
700 | 1 | a Murphy, Rachelu Univ British Columbia, Sch Populat Publ & Hlth, Ctr Excellence Canc Prevent, Fac Med, Vancouver, BC, Canada.4 aut |
700 | 1 | a Tintle, Nathanu Dordt Univ, Dept Math & Stat, Sioux Ctr, IA USA.4 aut |
700 | 1 | a Yu, Chaoyu Ianu Univ Washington, Sch Publ Hlth, Dept Biostat, Seattle, WA 98195 USA.4 aut |
700 | 1 | a Brouwer, Ingeborg A.u Vrije Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Dept Hlth Sci, Fac Sci, Amsterdam, Netherlands.4 aut |
700 | 1 | a Chien, Kuo-Liongu Natl Taiwan Univ, Inst Epidemiol & Prevent Med, Coll Publ Hlth, Taipei, Taiwan.;Taipei Vet Gen Hosp, Div Cardiol, Dept Med, Taipei, Taiwan.4 aut |
700 | 1 | a Chen, Yun-yuu Natl Taiwan Univ, Inst Epidemiol & Prevent Med, Coll Publ Hlth, Taipei, Taiwan.;Taipei Vet Gen Hosp, Div Cardiol, Dept Med, Taipei, Taiwan.4 aut |
700 | 1 | a Wood, Alexis C.u USDA ARS, Childrens Nutr Res Ctr, Dept Pediat, Baylor Coll Med, Houston, TX USA.4 aut |
700 | 1 | a del Gobbo, Liana C.u Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, Stanford, CA 94305 USA.4 aut |
700 | 1 | a Djousse, Lucu Harvard Med Sch, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Div Aging, 75 Francis St, Boston, MA 02115 USA.4 aut |
700 | 1 | a Geleijnse, Johanna M.u Wageningen Univ, Div Human Nutr & Hlth, Wageningen, Netherlands.4 aut |
700 | 1 | a Giles, Graham G.u Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Parkville, Vic, Australia.;Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia.4 aut |
700 | 1 | a de Goede, Janetteu Wageningen Univ, Div Human Nutr & Hlth, Wageningen, Netherlands.4 aut |
700 | 1 | a Gudnason, Vilmunduru Iceland Heart Assoc Res Inst, Kopavogur, Iceland.4 aut |
700 | 1 | a Harris, William S.u Univ South Dakota, Sanford Sch Med, Dept Internal Med, Sioux Falls, SD USA.;OmegaQuant Analyt, Sioux Falls, SD USA.4 aut |
700 | 1 | a Hodge, Allisonu Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Parkville, Vic, Australia.4 aut |
700 | 1 | a Hu, Franku Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.4 aut |
700 | 1 | a Koulman, Albertu Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.;Univ Cambridge, Natl Inst Hlth Res, Addenbrookes Hosp, Biomed Res Ctr,Core Nutr Biomarker Lab, Cambridge, England.;Univ Cambridge, Natl Inst Hlth Res, Addenbrookes Hosp, Biomed Res Ctr,Core Metabol & Lipid Lab, Cambridge, England.;MRC, Elsie Widdowson Lab, Cambridge, England.4 aut |
700 | 1 | a Laakso, Markkuu Univ Eastern Finland, Inst Clin Med, Internal Med, Kuopio, Finland.;Kuopio Univ Hosp, Dept Med, Kuopio, Finland.4 aut |
700 | 1 | a Lind, Larsu Uppsala universitet,Klinisk epidemiologi4 aut0 (Swepub:uu)larslind |
700 | 1 | a Lin, Hung-Juu Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan.4 aut |
700 | 1 | a McKnight, Barbarau Univ Washington, Sch Publ Hlth, Dept Biostat, Seattle, WA 98195 USA.4 aut |
700 | 1 | a Rajaobelina, Kalinau Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France.4 aut |
700 | 1 | a Risérus, Ulf,d 1967-u Uppsala universitet,Klinisk nutrition och metabolism4 aut0 (Swepub:uu)ulfriser |
700 | 1 | a Robinson, Jennifer G.u Univ Iowa, Coll Publ Hlth, Dept Epidemiol, Prevent Intervent Ctr, Iowa City, IA USA.4 aut |
700 | 1 | a Samieri, Ceciliau Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France.4 aut |
700 | 1 | a Senn, Mackenzieu USDA ARS, Childrens Nutr Res Ctr, Dept Pediat, Baylor Coll Med, Houston, TX USA.4 aut |
700 | 1 | a Siscovick, David S.u New York Acad Med, New York, NY USA.4 aut |
700 | 1 | a Soedamah-Muthu, Sabita S.u Wageningen Univ, Div Human Nutr & Hlth, Wageningen, Netherlands.;Tilburg Univ, Dept Med & Clin Psychol, Ctr Res Psychol & Somat Disorders, Tilburg, Netherlands.;Univ Reading, Inst Food Nutr & Hlth, Reading, Berks, England.4 aut |
700 | 1 | a Sotoodehnia, Nonau Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.4 aut |
700 | 1 | a Sun, Qiu Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.4 aut |
700 | 1 | a Tsai, Michael Y.u Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA.4 aut |
700 | 1 | a Tuomainen, Tomi-Pekkau Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.4 aut |
700 | 1 | a Uusitupa, Mattiu Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.4 aut |
700 | 1 | a Wagenknecht, Lynne E.u Wake Forest Sch Med, Publ Hlth Sci, Winston Salem, NC 27101 USA.4 aut |
700 | 1 | a Wareham, Nick J.u Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.4 aut |
700 | 1 | a Wu, Jason H. Y.u Univ New South Wales, George Inst Global Hlth, Fac Med, Sydney, NSW, Australia.4 aut |
700 | 1 | a Micha, Renatau Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA.4 aut |
700 | 1 | a Lemaitre, Rozenn N.u Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.4 aut |
700 | 1 | a Mozaffarian, Dariushu Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA.4 aut |
700 | 1 | a Forouhi, Nita G.u Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.4 aut |
710 | 2 | a Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.b Univ Washington, Dept Epidemiol, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA.4 org |
773 | 0 | t PLoS Medicined : Public Library of Science (PLoS)g 17:6q 17:6x 1549-1277x 1549-1676 |
856 | 4 | u https://doi.org/10.1371/journal.pmed.1003102y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1472630/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1003102&type=printable |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-420893 |
856 | 4 8 | u https://doi.org/10.1371/journal.pmed.1003102 |
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