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Composite GRFS and ...
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Mehta, Rohtesh S.Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat, Div Canc Med, Houston, TX 77030 USA.
(author)
Composite GRFS and CRFS Outcomes After Adult Alternative Donor HCT
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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American Society of Clinical Oncology (ASCO),2020
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Numbers
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LIBRIS-ID:oai:DiVA.org:uu-420898
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-420898URI
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https://doi.org/10.1200/JCO.19.00396DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:144397635URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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PURPOSE There is no consensus on the best choice of an alternative donor (umbilical cord blood [UCB], haploidentical, one-antigen mismatched [7/8]-bone marrow [BM], or 7/8-peripheral blood [PB]) for hematopoietic cell transplantation (HCT) for patients lacking an HLA-matched related or unrelated donor.METHODS We report composite end points of graft-versus-host disease (GVHD)-free relapse-free survival (GRFS) and chronic GVHD (cGVHD)-free relapse-free survival (CRFS) in 2,198 patients who underwent UCB (n = 838), haploidentical (n = 159), 7/8-BM (n = 241), or 7/8-PB (n = 960) HCT. All groups were divided by myeloablative conditioning (MAC) intensity or reduced intensity conditioning (RIC), except haploidentical group in which most received RIC. To account for multiple testing, P < .0071 in multivariable analysis and P < .00025 in direct pairwise comparisons were considered statistically significant.RESULTS In multivariable analysis, haploidentical group had the best GRFS, CRFS, and overall survival (OS). In the direct pairwise comparison of other groups, among those who received MAC, there was no difference in GRFS or CRFS among UCB, 7/8-BM, and 7/8-PB with serotherapy (alemtuzumab or antithymocyte globulin) groups. In contrast, the 7/8-PB without serotherapy group had significantly inferior GRFS, higher cGVHD, and a trend toward worse CRFS (hazard ratio [HR], 1.38; 95% CI, 1.13 to 1.69; P = .002) than the 7/8-BM group and higher cGVHD and trend toward inferior CRFS (HR, 1.36; 95% CI, 1.14 to 1.63; P = .0006) than the UCB group. Among patients with RIC, all groups had significantly inferior GRFS and CRFS compared with the haploidentical group.CONCLUSION Recognizing the limitations of a registry retrospective analysis and the possibility of center selection bias in choosing donors, our data support the use of UCB, 7/8-BM, or 7/8-PB (with serotherapy) grafts for patients undergoing MAC HCT and haploidentical grafts for patients undergoing RIC HCT. The haploidentical group had the best GRFS, CRFS, and OS of all groups.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Holtan, Shernan G.Univ Minnesota, Minneapolis, MN USA.
(author)
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Wang, TaoMed Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res CIBMTR, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Div Biostat, Inst Hlth & Equity, Milwaukee, WI 53226 USA.
(author)
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Hemmer, Michael T.Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res CIBMTR, Milwaukee, WI 53226 USA.
(author)
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Spellman, Stephen R.Be Match, CIBMTR, Natl Marrow Donor Program, Minneapolis, MN USA.
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Arora, MuktaUniv Minnesota, Med Ctr, Dept Med, Div Hematol Oncol & Transplantat, Minneapolis, MN 55455 USA.
(author)
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Couriel, Daniel R.Utah Blood & Marrow Transplant Program, Salt Lake City, UT USA.
(author)
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Alousi, Amin M.Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat, Div Canc Med, Houston, TX 77030 USA.
(author)
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Pidala, JosephH Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL USA.
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Abdel-Azim, HishamUniv Southern Calif, Childrens Hosp Los Angeles, Keck Sch Med, Div Hematol Oncol & Blood & Marrow Transplanta, Los Angeles, CA 90007 USA.
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Agrawal, VaibhavIndiana Univ, Sch Med, Div Hematol Oncol, Indianapolis, IN USA.
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Ahmed, IbrahimChildrens Mercy Hosp & Clin, Dept Hematol Oncol & Bone Marrow Transplantat, Kansas City, MO USA.
(author)
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Al-Homsi, A. SamerNYU, Langone Med Ctr, New York, NY USA.
(author)
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Aljurf, MahmoudKing Faisal Specialist Hosp Ctr & Res, Dept Oncol, Riyadh, Saudi Arabia.
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Antin, Joseph H.Dana Farber Canc Inst, Dept Med Oncol, Div Hematol Malignancies, Boston, MA 02115 USA.
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Askar, MedhatBaylor Univ, Med Ctr, Dept Pathol & Lab Med, Dallas, TX USA.
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Auletta, Jeffery J.Nationwide Childrens Hosp, Div Hematol Oncol Bone Marrow Transplant & Infect, Blood & Marrow Transplant Program, Columbus, OH USA.;Nationwide Childrens Hosp, Div Hematol Oncol Bone Marrow Transplant & Infect, Host Def Program, Columbus, OH USA.
(author)
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Bhatt, Vijaya RajUniv Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Omaha, NE USA.
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Chee, LynetteRoyal Melbourne Hosp, City Campus, Melbourne, Vic, Australia.
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Chhabra, SaurabhMed Coll Wisconsin, Dept Med, Div Hematol Oncol, Milwaukee, WI 53226 USA.
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Daly, AndrewTom Baker Canc Clin, Calgary, AB, Canada.
(author)
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DeFilipp, ZachariahMassachusetts Gen Hosp, Blood & Marrow Transplant Program, Boston, MA 02114 USA.
(author)
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Gajewski, JamesOregon Hlth & Sci Univ, Portland, OR 97201 USA.
(author)
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Gale, Robert PeterImperial Coll London, Div Expt Med, Dept Med, Hematol Res Ctr, London, England.
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Gergis, UsamaNew York Presbyterian Hosp, Dept Med Oncol, Hematolg Malignancies & Bone Marrow Transplant, Weill Cornell Med Ctr, New York, NY USA.
(author)
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Hematti, PeimanUniv Wisconsin Hosp & Clin, Dept Med, Div Hematol Oncol Bone Marrow Transplantat, Madison, WI 53792 USA.
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Hildebrandt, Gerhard C.Univ Kentucky, Markey Canc Ctr, Lexington, KY USA.
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Hogan, William J.Mayo Clin, Div Hematol Bone Marrow Transplantat, Rochester, MN USA.
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Inamoto, YoshihiroNatl Canc Ctr, Div Hematopoiet Stem Cell Transplantat, Tokyo, Japan.
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Martino, RodrigoHosp Santa Creu Sant & Pau, Div Clin Hematol, Barcelona, Spain.
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Majhail, Navneet S.Cleveland Clin, Taussig Canc Inst, Blood & Marrow Transplant Program, Cleveland, OH 44106 USA.
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Marks, David I.Univ Hosp Bristol, Adult Bone Marrow Transplant, Natl Hlth Serv Trust, Bristol, Avon, England.
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Nishihori, TaigaH Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL USA.
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Olsson, RichardUppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Translat Cell Therapy Res, Clintec, Stockholm, Sweden.(Swepub:uu)riols677
(author)
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Pawarode, AttapholUniv Michigan, Sch Med, Blood & Marrow Transplantat Program, Div Hematol Oncol,Dept Internal Med, Ann Arbor, MI USA.
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Diaz, Miguel AngelHosp Infantil Univ Nino Jesus, Dept Hematol Oncol, Madrid, Spain.
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Prestidge, TimStarship Childrens Hosp, Blood & Canc Ctr, Auckland, New Zealand.
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Rangarajan, Hemalatha G.Nationwide Childrens Hosp, Div Hematol Oncol Bone Marrow Transplant & Infect, Blood & Marrow Transplant Program, Columbus, OH USA.;Nationwide Childrens Hosp, Div Hematol Oncol Bone Marrow Transplant & Infect, Host Def Program, Columbus, OH USA.
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Ringden, OlleKarolinska Institutet
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Saad, AymanOhio State Univ, Div Hematol, Columbus, OH 43210 USA.
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Savani, Bipin N.Vanderbilt Univ, Med Ctr, Dept Pediat, Div Pediat Hematol Oncol, Nashville, TN 37232 USA.
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Schoemans, HeleneUniv Hosp Leuven, Leuven, Belgium.;Katholieke Univ Leuven, Leuven, Belgium.
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Seo, SachikoNatl Canc Res Ctr East, Dept Hematol & Oncol, Chiba, Japan.
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Schultz, Kirk R.Univ British Columbia, British Columbias Childrens Hosp, Dept Pediat Hematol Oncol & Bone Marrow Transplan, Vancouver, BC, Canada.
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Solh, MelhemNorthside Hosp, Blood & Marrow Transplant Grp Georgia, Atlanta, GA USA.
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Spitzer, ThomasTom Baker Canc Clin, Calgary, AB, Canada.
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Storek, JanUniv Calgary, Dept Med, Calgary, AB, Canada.
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Teshima, TakanoriHokkaido Univ Hosp, Sapporo, Hokkaido, Japan.
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Verdonck, Leo F.Isala Clin, Dept Hematol Oncol, Zwolle, Netherlands.
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Wirk, BaldeepSeattle Canc Care Alliance, Div Bone Marrow Transplant, Seattle, WA USA.
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Yared, Jean A.Univ Maryland, Blood & Marrow Transplantat Program, Greenebaum Comprehens Canc Ctr, Div Hematol Oncol,Dept Med, Baltimore, MD 21201 USA.
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Cahn, Jean-YvesCHU Grenoble Alpes, Dept Hematol, Grenoble, France.
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Weisdorf, Daniel J.Univ Minnesota, Minneapolis, MN USA.
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Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat, Div Canc Med, Houston, TX 77030 USA.Univ Minnesota, Minneapolis, MN USA.
(creator_code:org_t)
Related titles
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In:Journal of Clinical Oncology: American Society of Clinical Oncology (ASCO)38:18, s. 2062-20760732-183X1527-7755
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Mehta, Rohtesh S ...
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Holtan, Shernan ...
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Wang, Tao
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Hemmer, Michael ...
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Spellman, Stephe ...
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Arora, Mukta
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Couriel, Daniel ...
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Alousi, Amin M.
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Pidala, Joseph
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Abdel-Azim, Hish ...
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Agrawal, Vaibhav
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Ahmed, Ibrahim
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Al-Homsi, A. Sam ...
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Aljurf, Mahmoud
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Antin, Joseph H.
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Askar, Medhat
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Auletta, Jeffery ...
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Bhatt, Vijaya Ra ...
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Chee, Lynette
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Chhabra, Saurabh
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Daly, Andrew
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DeFilipp, Zachar ...
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Gajewski, James
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Gale, Robert Pet ...
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Gergis, Usama
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Hematti, Peiman
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Hildebrandt, Ger ...
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Hogan, William J ...
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Inamoto, Yoshihi ...
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Martino, Rodrigo
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Majhail, Navneet ...
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Marks, David I.
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Nishihori, Taiga
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Olsson, Richard
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Pawarode, Attaph ...
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Diaz, Miguel Ang ...
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Prestidge, Tim
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Rangarajan, Hema ...
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Ringden, Olle
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Saad, Ayman
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Savani, Bipin N.
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Schoemans, Helen ...
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Seo, Sachiko
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Schultz, Kirk R.
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Solh, Melhem
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Spitzer, Thomas
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Storek, Jan
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Teshima, Takanor ...
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Verdonck, Leo F.
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Wirk, Baldeep
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Yared, Jean A.
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Cahn, Jean-Yves
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Weisdorf, Daniel ...
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- MEDICAL AND HEALTH SCIENCES
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and Hematology
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Uppsala University
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Karolinska Institutet