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  • Tengvall, Katarina,1980-Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Lindbladtohlab (author)

Transcriptomes from German shepherd dogs reveal differences in immune activity between atopic dermatitis affected and control skin

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-06-18
  • Springer Science and Business Media LLC,2020
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-420920
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-420920URI
  • https://doi.org/10.1007/s00251-020-01169-3DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:143995814URI
  • https://res.slu.se/id/publ/112365URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Canine atopic dermatitis (CAD) is an inflammatory and pruritic allergic skin disease with both genetic and environmental risk factors described. We performed mRNA sequencing of non-lesional axillary skin biopsies from nine German shepherd dogs. Obtained RNA sequences were mapped to the dog genome (CanFam3.1) and a high-quality skin transcriptome was generated with 23,510 expressed gene transcripts. Differentially expressed genes (DEGs) were defined by comparing three controls to five treated CAD cases. Using a leave-one-out analysis, we identified seven DEGs: five known to encode proteins with functions related to an activated immune system (CD209, CLEC4G, LOC102156842 (lipopolysaccharide-binding protein-like), LOC480601 (regakine-1-like), LOC479668 (haptoglobin-like)), one (OBP) encoding an odorant-binding protein potentially connected to rhinitis, and the last (LOC607095) encoding a novel long non-coding RNA. Furthermore, high mRNA expression of inflammatory genes was found in axillary skin from an untreated mild CAD case compared with healthy skin. In conclusion, we define genes with different expression patterns in CAD case skin helping us understand post-treatment atopic skin. Further studies in larger sample sets are warranted to confirm and to transfer these results into clinical practice.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Bergvall, KerstinSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences(Swepub:slu)47499 (author)
  • Olsson, MKarolinska Inst, Ctr Mol Med, Dept Med, Div Rheumatol, Solna, Sweden. (author)
  • Ardesjö-Lundgren, BritaUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi,Swedish Univ Agr Sci, Dept Clin Sci, Uppsala, Sweden.,Uppsala University(Swepub:slu)96398 (author)
  • Farias, F H GWashington Univ, Dept Psychiat, Sch Med, St Louis, MO 63110 USA. (author)
  • Kierczak, Marcin,1981-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär evolution(Swepub:uu)makie499 (author)
  • Hedhammar, ÅkeSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences(Swepub:slu)49648 (author)
  • Lindblad-Toh, KerstinUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.(Swepub:uu)kerli865 (author)
  • Andersson, GöranSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics(Swepub:slu)50422 (author)
  • Uppsala universitetInstitutionen för medicinsk biokemi och mikrobiologi (creator_code:org_t)
  • Sveriges lantbruksuniversitet

Related titles

  • In:Immunogenetics: Springer Science and Business Media LLC72:5, s. 315-3230093-77111432-1211

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