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The tuatara genome ...
The tuatara genome reveals ancient features of amniote evolution
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- Gemmell, Neil J. (author)
- Univ Otago, Dept Anat, Dunedin, New Zealand
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- Rutherford, Kim (author)
- Univ Otago, Dept Anat, Dunedin, New Zealand
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- Prost, Stefan (author)
- Senckenberg Museum, LOEWE Ctr Translat Biodivers Genom, Frankfurt, Germany; Natl Zool Garden, South African Natl Biodivers Inst, Pretoria, South Africa
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- Tollis, Marc (author)
- Arizona State Univ, Sch Life Sci, Tempe, AZ USA; No Arizona Univ, Sch Informat Comp & Cyber Syst, Flagstaff, AZ 86011 USA
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- Winter, David (author)
- Massey Univ, Sch Fundamental Sci, Palmerston North, New Zealand
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- Macey, J. Robert (author)
- Peralta Genom Inst, Oakland, CA USA
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- Adelson, David L. (author)
- Univ Adelaide, Sch Biol Sci, Adelaide, SA, Australia
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- Suh, Alexander (author)
- Uppsala universitet,Evolutionsbiologi,Systematisk biologi
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- Bertozzi, Terry (author)
- Univ Adelaide, Sch Biol Sci, Adelaide, SA, Australia; South Australian Museum, Evolutionary Biol Unit, Adelaide, SA, Australia
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- Grau, José H. (author)
- Amedes Med Dienstleistungen, Amedes Genet, Berlin, Germany; Humboldt Univ, Leibniz Inst Evolut & Biodiversitatsforsch, Museum Nat Kunde Berlin, Berlin, Germany
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- Organ, Chris (author)
- Montana State Univ, Dept Earth Sci, Bozeman, MT 59717 USA
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- Gardner, Paul P. (author)
- Univ Otago, Dept Biochem, Dunedin, New Zealand
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- Muffato, Matthieu (author)
- European Bioinformat Inst, European Mol Biol Lab, Hinxton, England
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- Patricio, Mateus (author)
- European Bioinformat Inst, European Mol Biol Lab, Hinxton, England
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- Billis, Konstantinos (author)
- European Bioinformat Inst, European Mol Biol Lab, Hinxton, England
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- Martin, Fergal J. (author)
- European Bioinformat Inst, European Mol Biol Lab, Hinxton, England
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- Flicek, Paul (author)
- European Bioinformat Inst, European Mol Biol Lab, Hinxton, England
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- Petersen, Bent (author)
- Univ Copenhagen, Fac Hlth & Med Sci, GLOBE Inst, Sect Evolutionary Genom, Copenhagen, Denmark
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- Kang, Lin (author)
- Edward Via Coll Osteopath Med, Blacksburg, VA USA
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- Michalak, Pawel (author)
- Edward Via Coll Osteopath Med, Blacksburg, VA USA; Virginia Maryland Coll Vet Med, Ctr One Hlth Res, Blacksburg, VA USA; Univ Haifa, Inst Evolut, Haifa, Israel
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- Buckley, Thomas R. (author)
- Manaaki Whenua Landcare Res, Auckland, New Zealand; Univ Auckland, Sch Biol Sci, Auckland, New Zealand
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- Wilson, Melissa (author)
- Arizona State Univ, Sch Life Sci, Tempe, AZ USA
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- Cheng, Yuanyuan (author)
- Univ Sydney, Sch Life & Environm Sci, Sydney, NSW, Australia
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- Miller, Hilary (author)
- Biomatters, Auckland, New Zealand
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- Schott, Ryan K. (author)
- Smithsonian Inst, Natl Museum Nat Hist, Dept Vertebrate Zool, Washington, DC 20560 USA
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- Jordan, Melissa D. (author)
- New Zealand Inst Plant & Food Res, Auckland, New Zealand
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- Newcomb, Richard D. (author)
- New Zealand Inst Plant & Food Res, Auckland, New Zealand
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- Arroyo, José Ignacio (author)
- Pontificia Univ Catolica Chile, Fac Ciencias Biol, Dept Ecol, Santiago, Chile
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- Valenzuela, Nicole (author)
- Iowa State Univ, Dept Ecol Evolut & Organismal Biol, Ames, IA USA
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- Hore, Tim A. (author)
- Univ Otago, Dept Anat, Dunedin, New Zealand
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- Renart, Jaime (author)
- CSIC UAM, Inst Invest Biomed Alberto Sols, Madrid, Spain
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- Peona, Valentina (author)
- Uppsala universitet,Evolutionsbiologi,Systematisk biologi
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- Peart, Claire R. (author)
- Uppsala universitet,Evolutionsbiologi,Ludwig Maximilian Univ Munich, Fac Biol, Div Evolutionary Biol, Planegg Martinsried, Germany
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- Warmuth, Vera M. (author)
- Uppsala universitet,Evolutionsbiologi,Ludwig Maximilian Univ Munich, Fac Biol, Div Evolutionary Biol, Planegg Martinsried, Germany
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- Zeng, Lu (author)
- Univ Adelaide, Sch Biol Sci, Adelaide, SA, Australia
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- Kortschak, R. Daniel (author)
- Univ Adelaide, Sch Biol Sci, Adelaide, SA, Australia
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- Raison, Joy M. (author)
- Univ Adelaide, Sch Biol Sci, Adelaide, SA, Australia
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- Velásquez Zapata, Valeria (author)
- Iowa State Univ, Dept Ecol Evolut & Organismal Biol, Ames, IA USA
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- Wu, Zhiqiang (author)
- Iowa State Univ, Dept Ecol Evolut & Organismal Biol, Ames, IA USA
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- Santesmasses, Didac (author)
- Univ Pompeu Fabra UPF, Barcelona Inst Sci & Technol, Ctr Genom Regulat CRG, Barcelona, Spain
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- Mariotti, Marco (author)
- Univ Pompeu Fabra UPF, Barcelona Inst Sci & Technol, Ctr Genom Regulat CRG, Barcelona, Spain
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- Guigó, Roderic (author)
- Univ Pompeu Fabra UPF, Barcelona Inst Sci & Technol, Ctr Genom Regulat CRG, Barcelona, Spain
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- Rupp, Shawn M. (author)
- Arizona State Univ, Sch Life Sci, Tempe, AZ USA
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- Twort, Victoria G. (author)
- Manaaki Whenua Landcare Res, Auckland, New Zealand; Univ Auckland, Sch Biol Sci, Auckland, New Zealand
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- Dussex, Nicolas (author)
- Univ Otago, Dept Anat, Dunedin, New Zealand
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- Taylor, Helen (author)
- Univ Otago, Dept Anat, Dunedin, New Zealand
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- Abe, Hideaki (author)
- Univ Otago, Dept Anat, Dunedin, New Zealand
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- Bond, Donna M. (author)
- Univ Otago, Dept Anat, Dunedin, New Zealand
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- Paterson, James M. (author)
- Univ Canterbury, Sch Biol Sci, Christchurch, New Zealand
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- Mulcahy, Daniel G. (author)
- Smithsonian Inst, Natl Museum Nat Hist, Global Genome Initiat, Washington, DC 20560 USA
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- Gonzalez, Vanessa L. (author)
- Smithsonian Inst, Natl Museum Nat Hist, Global Genome Initiat, Washington, DC 20560 USA
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- Barbieri, Charles G. (author)
- Peralta Genom Inst, Oakland, CA USA
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- Demeo, Dustin P. (author)
- Peralta Genom Inst, Oakland, CA USA
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- Pabinger, Stephan (author)
- Austrian Inst Technol AIT, Ctr Hlth & Bioresources, Mol Diagnost, Vienna, Austria
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- Van Stijn, Tracey (author)
- AgResearch, Invermay Agr Ctr, Mosgiel, New Zealand
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- Clarke, Shannon (author)
- AgResearch, Invermay Agr Ctr, Mosgiel, New Zealand
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- Ryder, Oliver (author)
- San Diego Zoo Inst Conservat Res, Escondido, CA USA
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- Edwards, Scott V. (author)
- Harvard Univ, Dept Organism & Evolutionary Biol, Cambridge, MA 02138 USA.;Harvard Univ, Museum Comparat Zool, Cambridge, MA 02138 USA
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- Salzberg, Steven L. (author)
- Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD USA
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- Anderson, Lindsay (author)
- Victoria Univ Wellington, Sch Biol Sci, Wellington, New Zealand
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- Nelson, Nicola (author)
- Victoria Univ Wellington, Sch Biol Sci, Wellington, New Zealand
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- Stone, Clive (author)
- Ngatiwai Trust Board, Whangarei, New Zealand
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Smillie, Jim (author)
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Edmonds, Haydn (author)
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(creator_code:org_t)
- 2020-08-05
- 2020
- English.
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In: Nature. - : Springer Nature. - 0028-0836 .- 1476-4687. ; 584:7821, s. 403-409
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- The tuatara (Sphenodon punctatus)—the only living member of the reptilian order Rhynchocephalia (Sphenodontia), once widespread across Gondwana1,2—is an iconic species that is endemic to New Zealand2,3. A key link to the now-extinct stem reptiles (from which dinosaurs, modern reptiles, birds and mammals evolved), the tuatara provides key insights into the ancestral amniotes2,4. Here we analyse the genome of the tuatara, which—at approximately 5 Gb—is among the largest of the vertebrate genomes yet assembled. Our analyses of this genome, along with comparisons with other vertebrate genomes, reinforce the uniqueness of the tuatara. Phylogenetic analyses indicate that the tuatara lineage diverged from that of snakes and lizards around 250 million years ago. This lineage also shows moderate rates of molecular evolution, with instances of punctuated evolution. Our genome sequence analysis identifies expansions of proteins, non-protein-coding RNA families and repeat elements, the latter of which show an amalgam of reptilian and mammalian features. The sequencing of the tuatara genome provides a valuable resource for deep comparative analyses of tetrapods, as well as for tuatara biology and conservation. Our study also provides important insights into both the technical challenges and the cultural obligations that are associated with genome sequencing.
Subject headings
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Nature
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To the university's database
- By the author/editor
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Gemmell, Neil J.
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Rutherford, Kim
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Prost, Stefan
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Tollis, Marc
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Winter, David
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Macey, J. Robert
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show more...
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Adelson, David L ...
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Suh, Alexander
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Bertozzi, Terry
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Grau, José H.
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Organ, Chris
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Gardner, Paul P.
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Muffato, Matthie ...
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Patricio, Mateus
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Billis, Konstant ...
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Martin, Fergal J ...
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Flicek, Paul
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Petersen, Bent
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Kang, Lin
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Michalak, Pawel
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Buckley, Thomas ...
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Wilson, Melissa
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Cheng, Yuanyuan
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Miller, Hilary
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Schott, Ryan K.
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Jordan, Melissa ...
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Newcomb, Richard ...
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Arroyo, José Ign ...
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Valenzuela, Nico ...
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Hore, Tim A.
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Renart, Jaime
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Peona, Valentina
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Peart, Claire R.
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Warmuth, Vera M.
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Zeng, Lu
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Kortschak, R. Da ...
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Raison, Joy M.
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Velásquez Zapata ...
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Wu, Zhiqiang
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Santesmasses, Di ...
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Mariotti, Marco
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Guigó, Roderic
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Rupp, Shawn M.
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Twort, Victoria ...
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Dussex, Nicolas
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Taylor, Helen
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Abe, Hideaki
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Bond, Donna M.
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Paterson, James ...
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Mulcahy, Daniel ...
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Gonzalez, Vaness ...
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Barbieri, Charle ...
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Demeo, Dustin P.
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Pabinger, Stepha ...
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Van Stijn, Trace ...
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Clarke, Shannon
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Ryder, Oliver
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Edwards, Scott V ...
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Salzberg, Steven ...
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Anderson, Lindsa ...
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Nelson, Nicola
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Stone, Clive
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Smillie, Jim
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Edmonds, Haydn
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Evolutionary Bio ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
- Articles in the publication
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Nature
- By the university
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Uppsala University