Search: onr:"swepub:oai:DiVA.org:uu-421684" >
MiR-21 is up-regula...
MiR-21 is up-regulated in psoriasis and suppresses T cell apoptosis.
-
- Meisgen, Florian (author)
- Karolinska Institutet
-
- Xu, Ning (author)
- Karolinska Institutet
-
Wei, Tianling (author)
-
show more...
-
Janson, Peter C (author)
-
Obad, Susanna (author)
-
Broom, Oliver (author)
-
Nagy, Nikoletta (author)
-
Kauppinen, Sakari (author)
-
Kemény, Lajos (author)
-
- Ståhle, Mona (author)
- Karolinska Institutet
-
- Pivarcsi, Andor (author)
- Karolinska Institutet
-
- Sonkoly, Enikö (author)
- Karolinska Institutet
-
show less...
-
(creator_code:org_t)
- 2012-03-15
- 2012
- English.
-
In: Experimental dermatology. - : Wiley. - 0906-6705 .- 1600-0625. ; 21:4, s. 312-4
- Related links:
-
https://onlinelibrar...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- MicroRNAs are short non-coding RNAs that regulate gene expression. Previously, in a genome-wide screen, we found deregulation of microRNA expression in psoriasis skin. MicroRNA-21 (miR-21) is one of the microRNAs significantly up-regulated in psoriasis skin lesions. To identify the cell type responsible for the increased miR-21 level, we compared expression of miR-21 in epidermal cells and dermal T cells between psoriasis and healthy skin and found elevated levels of miR-21 in psoriasis in both cell types. In cultured T cells, expression of miR-21 increased markedly upon activation. To explore the function of miR-21 in primary human T helper cells, we inhibited miR-21 using a tiny seed-targeting LNA-anti-miR. Specific inhibition of miR-21 increased the apoptosis rate of activated T cells. Our results suggest that miR-21 suppresses apoptosis in activated T cells, and thus, overexpression of miR-21 may contribute to T cell-derived psoriatic skin inflammation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Meisgen, Florian
-
Xu, Ning
-
Wei, Tianling
-
Janson, Peter C
-
Obad, Susanna
-
Broom, Oliver
-
show more...
-
Nagy, Nikoletta
-
Kauppinen, Sakar ...
-
Kemény, Lajos
-
Ståhle, Mona
-
Pivarcsi, Andor
-
Sonkoly, Enikö
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Dermatology and ...
- Articles in the publication
-
Experimental der ...
- By the university
-
Uppsala University
-
Karolinska Institutet