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Constraints for mon...
Constraints for monocyte-derived dendritic cell functions under inflammatory conditions.
- Article/chapterEnglish2012
Publisher, publication year, extent ...
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2011-12-14
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Wiley,2012
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-421686
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421686URI
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https://doi.org/10.1002/eji.201141924DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:124082057URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The activation of TLRs expressed by macrophages or DCs, in the long run, leads to persistently impaired functionality. TLR signals activate a wide range of negative feedback mechanisms; it is not known, however, which of these can lead to long-lasting tolerance for further stimulatory signals. In addition, it is not yet understood how the functionality of monocyte-derived DCs (MoDCs) is influenced in inflamed tissues by the continuous presence of stimulatory signals during their differentiation. Here we studied the role of a wide range of DC-inhibitory mechanisms in a simple and robust model of MoDC inactivation induced by early TLR signals during differentiation. We show that the activation-induced suppressor of cytokine signaling 1 (SOCS1), IL-10, STAT3, miR146a and CD150 (SLAM) molecules possessed short-term inhibitory effects on cytokine production but did not induce persistent DC inactivation. On the contrary, the LPS-induced IRAK-1 downregulation could alone lead to persistent MoDC inactivation. Studying cellular functions in line with the activation-induced negative feedback mechanisms, we show that early activation of developing MoDCs allowed only a transient cytokine production that was followed by the downregulation of effector functions and the preservation of a tissue-resident non-migratory phenotype.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Szabo, Attila
(author)
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Beltrame, Luca
(author)
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Vivar, Nancy
(author)
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Pivarcsi, AndorKarolinska Institutet(Swepub:uu)andpi932
(author)
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Lanyi, Arpad
(author)
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Cavalieri, Duccio
(author)
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Rajnavölgyi, Eva
(author)
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Rethi, BenceKarolinska Institutet
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:European Journal of Immunology: Wiley42:2, s. 458-690014-29801521-4141
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