Search: onr:"swepub:oai:DiVA.org:uu-421686" > Constraints for mon...
Fältnamn | Indikatorer | Metadata |
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000 | 03488naa a2200457 4500 | |
001 | oai:DiVA.org:uu-421686 | |
003 | SwePub | |
008 | 201012s2012 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:124082057 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4216862 URI |
024 | 7 | a https://doi.org/10.1002/eji.2011419242 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1240820572 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Fekete, Tünde4 aut |
245 | 1 0 | a Constraints for monocyte-derived dendritic cell functions under inflammatory conditions. |
264 | c 2011-12-14 | |
264 | 1 | b Wiley,c 2012 |
338 | a print2 rdacarrier | |
520 | a The activation of TLRs expressed by macrophages or DCs, in the long run, leads to persistently impaired functionality. TLR signals activate a wide range of negative feedback mechanisms; it is not known, however, which of these can lead to long-lasting tolerance for further stimulatory signals. In addition, it is not yet understood how the functionality of monocyte-derived DCs (MoDCs) is influenced in inflamed tissues by the continuous presence of stimulatory signals during their differentiation. Here we studied the role of a wide range of DC-inhibitory mechanisms in a simple and robust model of MoDC inactivation induced by early TLR signals during differentiation. We show that the activation-induced suppressor of cytokine signaling 1 (SOCS1), IL-10, STAT3, miR146a and CD150 (SLAM) molecules possessed short-term inhibitory effects on cytokine production but did not induce persistent DC inactivation. On the contrary, the LPS-induced IRAK-1 downregulation could alone lead to persistent MoDC inactivation. Studying cellular functions in line with the activation-induced negative feedback mechanisms, we show that early activation of developing MoDCs allowed only a transient cytokine production that was followed by the downregulation of effector functions and the preservation of a tissue-resident non-migratory phenotype. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
700 | 1 | a Szabo, Attila4 aut |
700 | 1 | a Beltrame, Luca4 aut |
700 | 1 | a Vivar, Nancy4 aut |
700 | 1 | a Pivarcsi, Andoru Karolinska Institutet4 aut0 (Swepub:uu)andpi932 |
700 | 1 | a Lanyi, Arpad4 aut |
700 | 1 | a Cavalieri, Duccio4 aut |
700 | 1 | a Rajnavölgyi, Eva4 aut |
700 | 1 | a Rethi, Benceu Karolinska Institutet4 aut |
710 | 2 | a Karolinska Institutet4 org |
773 | 0 | t European Journal of Immunologyd : Wileyg 42:2, s. 458-69q 42:2<458-69x 0014-2980x 1521-4141 |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.201141924 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421686 |
856 | 4 8 | u https://doi.org/10.1002/eji.201141924 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:124082057 |
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