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  • Sonkoly, Eniko (author)

Identification and characterization of a novel, psoriasis susceptibility-related noncoding RNA gene, PRINS.

  • Article/chapterEnglish2005

Publisher, publication year, extent ...

  • 2005
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:uu-421711
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421711URI
  • https://doi.org/10.1074/jbc.M501704200DOI

Supplementary language notes

  • Language:English
  • Summary in:English &language:-1_t

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • To identify genetic factors contributing to psoriasis susceptibility, gene expression profiles of uninvolved epidermis from psoriatic patients and epidermis from healthy individuals were compared. Besides already characterized genes, we identified a cDNA with yet unknown functions, which we further characterized and named PRINS (Psoriasis susceptibility-related RNA Gene Induced by Stress). In silico structural and homology studies suggested that PRINS may function as a noncoding RNA. PRINS harbors two Alu elements, it is transcribed by RNA polymerase II, and it is expressed at different levels in various human tissues. Real time reverse transcription-PCR analysis showed that PRINS was expressed higher in the uninvolved epidermis of psoriatic patients compared with both psoriatic lesional and healthy epidermis, suggesting a role for PRINS in psoriasis susceptibility. PRINS is regulated by the proliferation and differentiation state of keratinocytes. Treatment with T-lymphokines, known to precipitate psoriatic symptoms, decreased PRINS expression in the uninvolved psoriatic but not in healthy epidermis. Real time reverse transcription-PCR analysis showed that stress signals such as ultraviolet-B irradiation, viral infection (herpes simplex virus), and translational inhibition increased the RNA level of PRINS. Gene-specific silencing of PRINS by RNA interference revealed that down-regulation of PRINS impairs cell viability after serum starvation but not under normal serum conditions. Our findings suggest that PRINS functions as a noncoding regulatory RNA, playing a protective role in cells exposed to stress. Furthermore, elevated PRINS expression in the epidermis may contribute to psoriasis susceptibility.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Bata-Csorgo, Zsuzsanna (author)
  • Pivarcsi, Andor (author)
  • Polyanka, Hilda (author)
  • Kenderessy-Szabo, Anna (author)
  • Molnar, Gergely (author)
  • Szentpali, Karoly (author)
  • Bari, Lilla (author)
  • Megyeri, Klara (author)
  • Mandi, Yvette (author)
  • Dobozy, Attila (author)
  • Kemeny, Lajos (author)
  • Szell, Marta (author)

Related titles

  • In:Journal of Biological Chemistry280:25, s. 24159-670021-92581083-351X

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