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A pooled analysis o...
A pooled analysis of 12 cohort studies of dietary fat, cholesterol and egg intake and ovarian cancer
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Genkinger, J M (author)
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Hunter, D J (author)
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Spiegelman, D (author)
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Anderson, K E (author)
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Beeson, W L (author)
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Buring, J E (author)
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Colditz, G A (author)
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Fraser, G E (author)
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Freudenheim, J L (author)
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Goldbohm, R A (author)
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Hankinson, S E (author)
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Koenig, K L (author)
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- Larsson, S C (author)
- Karolinska Institutet
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Leitzmann, M (author)
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McCullough, M L (author)
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Miller, A B (author)
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Rodriguez, C (author)
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Rohan, T E (author)
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Ross, J A (author)
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Schatzkin, A (author)
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Schouten, L J (author)
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Smit, E (author)
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Willett, W C (author)
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- Wolk, A (author)
- Karolinska Institutet
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Zeleniuch-Jacquotte, A (author)
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Zhang, S M M (author)
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Smith-Warner, S (author)
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(creator_code:org_t)
- Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA. Harvard Univ, Sch Med, Boston, MA USA. Harvard Univ, Sch Publ Hlth, Harvard Ctr Canc Prevent, Boston, MA 02115 USA. Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. Univ Minnesota, Sch Publ Hlth, Div Epidemiol, Minneapolis, MN 55455 USA. Loma Linda Univ, Sch Med, Ctr Hlth Res, Loma Linda, CA USA. Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 USA. SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USA. SPRINGER, 2006
- 2006
- English.
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In: Cancer Causes and Control. - Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA. Harvard Univ, Sch Med, Boston, MA USA. Harvard Univ, Sch Publ Hlth, Harvard Ctr Canc Prevent, Boston, MA 02115 USA. Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. Univ Minnesota, Sch Publ Hlth, Div Epidemiol, Minneapolis, MN 55455 USA. Loma Linda Univ, Sch Med, Ctr Hlth Res, Loma Linda, CA USA. Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 USA. SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USA. : SPRINGER. - 0957-5243 .- 1573-7225. ; 17:3, s. 273-285
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Abstract
Subject headings
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- Fat and cholesterol are theorized to promote ovarian carcinogenesis by increasing circulating estrogen levels. Although case-control studies have reported positive associations between total and saturated fat intake and ovarian cancer risk, two cohort studies have observed null associations. Dietary cholesterol and eggs have been positively associated with ovarian cancer risk. A pooled analysis was conducted on 12 cohort studies. Among 523,217 women, 2,132 incident epithelial ovarian cancer cases were identified. Study-specific relative risks (RR) and 95% confidence intervals (CI) were calculated by Cox proportional hazards models, and then pooled using a random effects model. Total fat intake was not associated with ovarian cancer risk (pooled multivariate RR = 1.08, 95% CI 0.86-1.34 comparing >= 45 to 30-< 35% of calories). No association was observed for monounsaturated, polyunsaturated, trans-unsaturated, animal and vegetable fat, cholesterol and egg intakes with ovarian cancer risk. A weakly positive, but non-linear association, was observed for saturated fat intake (pooled multivariate RR = 1.29, 95% CI: 1.01-1.66 comparing highest versus lowest decile). Results for histologic subtypes were similar. Overall, fat, cholesterol and egg intakes were not associated with ovarian cancer risk. The positive association for saturated fat intake at very high intakes merits further investigation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- diet
- fat
- cholesterol
- egg
- ovarian cancer
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Genkinger, J M
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Hunter, D J
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Spiegelman, D
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Anderson, K E
-
Beeson, W L
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Buring, J E
-
show more...
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Colditz, G A
-
Fraser, G E
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Freudenheim, J L
-
Goldbohm, R A
-
Hankinson, S E
-
Koenig, K L
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Larsson, S C
-
Leitzmann, M
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McCullough, M L
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Miller, A B
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Rodriguez, C
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Rohan, T E
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Ross, J A
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Schatzkin, A
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Schouten, L J
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Smit, E
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Willett, W C
-
Wolk, A
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Zeleniuch-Jacquo ...
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Zhang, S M M
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Smith-Warner, S
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Causes an ...
- By the university
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Uppsala University
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Karolinska Institutet