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Vaginal microbiota ...
Vaginal microbiota and human papillomavirus infection among young Swedish women
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- Cheng, Liqin (author)
- Karolinska Institutet
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- Norenhag, Johanna (author)
- Uppsala universitet,Reproduktionsbiologi
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- Hu, Yue O. O. (author)
- Karolinska Institutet
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- Brusselaers, Nele (author)
- Karolinska Institutet
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- Fransson, Emma, PhD, 1973- (author)
- Karolinska Institutet,Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning,Department of Microbiology, Tumor and Cell Biology, Centre for Translational Microbiome Research (CTMR), Karolinska Institutet, Stockholm, Sweden
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- Ährlund-Richter, Andreas (author)
- Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden
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- Guðnadóttir, Unnur (author)
- Karolinska Institutet
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- Angelidou, Pia (author)
- Department of Microbiology, Tumor and Cell Biology, Centre for Translational Microbiome Research (CTMR), Karolinska Institutet, Stockholm, Sweden
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- Zha, Yinghua (author)
- Department of Microbiology, Tumor and Cell Biology, Centre for Translational Microbiome Research (CTMR), Karolinska Institutet, Stockholm, Sweden
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- Hamsten, Marica (author)
- Karolinska Institutet
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- Schuppe-Koistinen, Ina (author)
- Karolinska Institutet
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- Olovsson, Matts, 1958- (author)
- Uppsala universitet,Reproduktionsbiologi
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- Engstrand, Lars (author)
- Karolinska Institutet
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- Du, Juan (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2020-10-12
- 2020
- English.
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In: npj Biofilms and Microbiomes. - : Springer Science and Business Media LLC. - 2055-5008. ; 6:1
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Abstract
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- Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases. To define the HPV-associated microbial community among a high vaccination coverage population, we carried out a cross-sectional study with 345 young Swedish women. The microbial composition and its association with HPV infection, including 27 HPV types, were analyzed. Microbial alpha-diversity was found significantly higher in the HPV-infected group (especially with oncogenic HPV types and multiple HPV types), compared with the HPV negative group. The vaginal microbiota among HPV-infected women was characterized by a larger number of bacterial vaginosis-associated bacteria (BVAB), Sneathia, Prevotella, and Megasphaera. In addition, the correlation analysis demonstrated that twice as many women with non-Lactobacillus-dominant vaginal microbiota were infected with oncogenic HPV types, compared with L. crispatus-dominated vaginal microbiota. The data suggest that HPV infection, especially oncogenic HPV types, is strongly associated with a non-Lactobacillus-dominant vaginal microbiota, regardless of age and vaccination status.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Cheng, Liqin
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Norenhag, Johann ...
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Hu, Yue O. O.
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Brusselaers, Nel ...
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Fransson, Emma, ...
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Ährlund-Richter, ...
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Guðnadóttir, Unn ...
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Angelidou, Pia
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Zha, Yinghua
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Hamsten, Marica
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Schuppe-Koistine ...
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Olovsson, Matts, ...
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Engstrand, Lars
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Du, Juan
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
- Articles in the publication
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npj Biofilms and ...
- By the university
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Uppsala University
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Karolinska Institutet