Vaginal microbiota and human papillomavirus infection among young Swedish women

De tre första författarna delar förstaförfattarskapet
Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases. To define the HPV-associated microbial community among a high vaccination coverage population, we carried out a cross-sectional study with 345 young Swedish women. The microbial composition and its association with HPV infection, including 27 HPV types, were analyzed. Microbial alpha-diversity was found significantly higher in the HPV-infected group (especially with oncogenic HPV types and multiple HPV types), compared with the HPV negative group. The vaginal microbiota among HPV-infected women was characterized by a larger number of bacterial vaginosis-associated bacteria (BVAB), Sneathia, Prevotella, and Megasphaera. In addition, the correlation analysis demonstrated that twice as many women with non-Lactobacillus-dominant vaginal microbiota were infected with oncogenic HPV types, compared with L. crispatus-dominated vaginal microbiota. The data suggest that HPV infection, especially oncogenic HPV types, is strongly associated with a non-Lactobacillus-dominant vaginal microbiota, regardless of age and vaccination status.

Norenhag, JohannaUppsala universitet,Reproduktionsbiologi(Swepub:uu)johno353 (author)
Hu, Yue O. O.Karolinska Institutet (author)
Brusselaers, NeleKarolinska Institutet (author)
Fransson, Emma,PhD,1973-Karolinska Institutet,Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning,Department of Microbiology, Tumor and Cell Biology, Centre for Translational Microbiome Research (CTMR), Karolinska Institutet, Stockholm, Sweden(Swepub:uu)emmfr204 (author)
Ährlund-Richter, AndreasDepartment of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden (author)
Guðnadóttir, UnnurKarolinska Institutet (author)
Angelidou, PiaDepartment of Microbiology, Tumor and Cell Biology, Centre for Translational Microbiome Research (CTMR), Karolinska Institutet, Stockholm, Sweden (author)
Zha, YinghuaDepartment of Microbiology, Tumor and Cell Biology, Centre for Translational Microbiome Research (CTMR), Karolinska Institutet, Stockholm, Sweden (author)
Hamsten, MaricaKarolinska Institutet (author)
Schuppe-Koistinen, InaKarolinska Institutet (author)
Olovsson, Matts,1958-Uppsala universitet,Reproduktionsbiologi(Swepub:uu)mattolov (author)
Engstrand, LarsKarolinska Institutet (author)
Du, JuanKarolinska Institutet (author)
Karolinska InstitutetReproduktionsbiologi (creator_code:org_t)

In:npj Biofilms and Microbiomes: Springer Science and Business Media LLC6:12055-5008

By the author/editor: Cheng, Liqin; Norenhag, Johann ...; Hu, Yue O. O.; Brusselaers, Nel ...; Fransson, Emma, ...; Ährlund-Richter, ...; show more...; Guðnadóttir, Unn ...; Angelidou, Pia; Zha, Yinghua; Hamsten, Marica; Schuppe-Koistine ...; Olovsson, Matts, ...; Engstrand, Lars; Du, Juan; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Obstetrics Gynae ...

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