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Search: onr:"swepub:oai:DiVA.org:uu-423169" > Knockdown of the α5...

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Knockdown of the α5 laminin chain affects differentiation of colorectal cancer cells and their sensitivity to chemotherapy

Maltseva, Diana (author)
Natl Res Univ Higher Sch Econ, Fac Biol & Biotechnol, Myasnitskaya Str 13-4, Moscow 117997, Russia; Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Miklukho Maklaya Str 16-10, Moscow 117997, Russia; Sci Res Ctr Bioclinicum, Ugreshskaya Str 2-85, Moscow 115088, Russia
Raygorodskaya, Maria (author)
Sci Res Ctr Bioclinicum, Ugreshskaya Str 2-85, Moscow 115088, Russia
Knyazev, Evgeny (author)
Natl Res Univ Higher Sch Econ, Fac Biol & Biotechnol, Myasnitskaya Str 13-4, Moscow 117997, Russia; Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Miklukho Maklaya Str 16-10, Moscow 117997, Russia
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Zgoda, Victor (author)
Inst Biomed Chem, Pogodinskaya Str 10, Moscow 119121, Russia
Tikhonova, Olga (author)
Inst Biomed Chem, Pogodinskaya Str 10, Moscow 119121, Russia
Zaidi, Shan (author)
George Mason Univ, Sch Syst Biol, Fairfax, VA 22030 USA
Nikulin, Sergey (author)
Natl Res Univ Higher Sch Econ, Fac Biol & Biotechnol, Myasnitskaya Str 13-4, Moscow 117997, Russia; Moscow Inst Phys & Technol, Inst Skiy 9, Dolgoprudnyi 141700, Russia
Baranova, Ancha (author)
George Mason Univ, Sch Syst Biol, Fairfax, VA 22030 USA; Moscow Inst Phys & Technol, Inst Skiy 9, Dolgoprudnyi 141700, Russia; Res Ctr Med Genet, Moskvorechye Str 1, Moscow 115522, Russia
Turchinovich, Andrey (author)
SciBerg eKfm, Birkenauer Str 7, D-68309 Mannheim, Germany
Rodin, Sergey (author)
Uppsala universitet,Institutionen för kirurgiska vetenskaper
Tonevitsky, Alexander (author)
Natl Res Univ Higher Sch Econ, Fac Biol & Biotechnol, Myasnitskaya Str 13-4, Moscow 117997, Russia; Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Miklukho Maklaya Str 16-10, Moscow 117997, Russia; Sci Res Ctr Bioclinicum, Ugreshskaya Str 2-85, Moscow 115088, Russia
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 (creator_code:org_t)
Elsevier BV, 2020
2020
English.
In: Biochimie. - : Elsevier BV. - 0300-9084 .- 1638-6183. ; 174, s. 107-116
Related links:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • The interaction of tumor cells with the extracellular matrix (ECM) may affect the rate of cancer progression and metastasis. One of the major components of ECM are laminins, the heterotrimeric glycoproteins consisting of α-, β-, and γ-chains (αβγ). Laminins interact with their cell surface receptors and, thus, regulate multiple cellular processes. In this work, we demonstrate that shRNA-mediated knockdown of the α5 laminin chain results in Wnt- and mTORC1-dependent partial dedifferentiation of colorectal cancer cells. Furthermore, we showed that this dedifferentiation involved activation of ER-stress signaling, pathway promoting the sensitivity of cells to 5-fluorouracil.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)

Keyword

Colorectal cancer
Laminin
Dedifferentiation
Intestinal epithelium stem cell marker
HT29
LAMA5

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