Considerations for the optimal management of antibiotic therapy in elderly patients

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: onr:"swepub:oai:DiVA.org:uu-423223" > Considerations for ...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Falcone, MarcoUniv Pisa, Dept Clin & Expt Med, Via Paradisa 2, I-56124 Pisa, Italy. (author)

Considerations for the optimal management of antibiotic therapy in elderly patients

Article/chapterEnglish2020

Publisher, publication year, extent ...

ELSEVIER SCI LTD,2020
electronicrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:uu-423223
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-423223URI
https://doi.org/10.1016/j.jgar.2020.02.022DOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:for swepub-publicationtype

Notes

Objectives: To maximise efficacy and minimise toxicity, special considerations are required for antibiotic prescription in elderly patients. This review aims to provide practical suggestions for the optimal management of antibiotic therapy in elderly patients. Methods: This was a narrative review. A literature search of published articles in the last 15 years on antibiotics and elderly patients was performed using the Cochrane Library and PubMed electronic databases. The three priority areas were identified: (i) pharmacokinetics/pharmacodynamics (PK/PD) for optimising dosage regimens and route of administration; (ii) antibiotic dosages in some special subpopulations; and (iii) treatment considerations relating to different antibiotic classes and their adverse events. Results: Clinicians should understand the altered PK/PD of drugs in this population owing to co-morbid conditions and normal physiological changes associated with ageing. The body of evidence justifies the need for individualised dose selection, especially in patients with impaired renal and liver function. Clinicians should be aware of the major drug-drug interactions commonly observed in the elderly as well as potential side effects. Conclusion: Antibiotic therapy in the elderly requires a comprehensive approach, including strategies to improve appropriate antibiotic prescribing, limit their use for uncomplicated infections and ensure the attainment of an optimal PK/PD target. To this purpose, further studies involving the elderly are needed to better understand the PK of antibiotics. Moreover, it is necessary to assess the role therapeutic drug monitoring in guiding antibiotic therapy in elderly patients in order to evaluate its impact on clinical outcome.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmakologi och toxikologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmacology and Toxicology hsv//eng
Elderly
Pharmacokinetics
Pharmacodynamics
Antibiotics
Dosage
Adverse events

Added entries (persons, corporate bodies, meetings, titles ...)

Paul, MicalTechnion Israel Inst Technol, Rambam Hlth Care Ctr, Div Infect Dis, Haifa, Israel.;Technion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Haifa, Israel. (author)
Tiseo, GiusyUniv Pisa, Dept Clin & Expt Med, Via Paradisa 2, I-56124 Pisa, Italy. (author)
Yahav, DafnaBeilinson Med Ctr, Rabin Med Ctr, Infect Dis Unit, Petah Tiqwa, Israel. (author)
Prendki, VirginieGeneva Univ Hosp, Dept Rehabil & Geriatr, Div Internal Med Aged, Geneva, Switzerland.;Univ Geneva, Hop Trois Chene, Geneva, Switzerland. (author)
Friberg, LenaUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)lenasimo (author)
Guerri, RobertoUniv Autonoma Barcelona, Hosp del Mar, Infect Dis Dept, Dept Med, Barcelona, Spain. (author)
Gavazzi, GaetanUniv Grenoble Alpes, Univ Hosp Grenoble Alpes, Univ Clin Geriatr, GREPI EA7408, Grenoble, France. (author)
Mussini, CristinaUniv Modena & Reggio Emilia, Clin Infect Dis, Modena, Italy. (author)
Tinelli, MarcoHosp Lodi, Div Infect & Trop Dis, Lodi, Italy. (author)
Univ Pisa, Dept Clin & Expt Med, Via Paradisa 2, I-56124 Pisa, Italy.Technion Israel Inst Technol, Rambam Hlth Care Ctr, Div Infect Dis, Haifa, Israel.;Technion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Haifa, Israel. (creator_code:org_t)

Related titles

In:Journal of Global Antimicrobial Resistance: ELSEVIER SCI LTD22, s. 325-3332213-71652213-7173

Internet link

Find in a library

Journal of Global Antimicrobial Resistance (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Falcone, Marco; Paul, Mical; Tiseo, Giusy; Yahav, Dafna; Prendki, Virgini ...; Friberg, Lena; show more...; Guerri, Roberto; Gavazzi, Gaetan; Mussini, Cristin ...; Tinelli, Marco; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Pharmacology and ...

Articles in the publication: Journal of Globa ...

By the university: Uppsala University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se