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GABA B receptor int...
GABA B receptor intracellular signaling : novel pathways for depressive disorder treatment?
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- Korczak, Maciej (author)
- Medical University of Warsaw, Warsaw, Poland
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- Kurowski, Przemysław (author)
- Medical University of Warsaw, Warsaw, Poland
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- Leśniak, Anna (author)
- Medical University of Warsaw, Warsaw, Poland
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- Gröndbladh, Alfhild, 1983- (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Filipowska, Anna (author)
- Silesian University of Technology, Zabrze, Poland
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- Bujalska-Zadrożny, Magdalena (author)
- Medical University of Warsaw, Warsaw, Poland
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(creator_code:org_t)
- Elsevier, 2020
- 2020
- English.
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In: European Journal of Pharmacology. - : Elsevier. - 0014-2999 .- 1879-0712. ; 885
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Affecting over 320 million people around the world, depression has become a formidable challenge for modern medicine. In addition, an increasing number of studies cast doubt on the monoamine theory of depressive disorder and, worryingly, antidepressant medications only significantly benefit patients with severe depression. Thus, it is not surprising that researchers have shown an increased interest in new theories attempting to explain the pathogenesis of this disease. One example is the excitatory/inhibitory transmission imbalance theory. These abnormalities involve glutamate and γ-aminobutyric acid (GABA) signaling. Studies on GABAB receptors and their antagonists are particularly promising for the treatment of depressive disorders. In this paper, intracellular pathways controlled by GABAB receptors and their links to depression are described, including the impact of ketamine on GABAergic synaptic transmission.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- Antidepressant drugs
- Depression
- Ion channels
- Neuroplasticity
- Neurotransmitters
- Receptors
- Farmaceutisk vetenskap
- Pharmaceutical Science
Publication and Content Type
- ref (subject category)
- art (subject category)
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