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G-Protein coupled r...
G-Protein coupled receptors : structure and function in drug discovery
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- Odoemelam, Chiemela S. (author)
- Nottingham Trent Univ, 50 Shakespeare St, Nottingham NG1 4FQ, England
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- Percival, Benita (author)
- Nottingham Trent Univ, 50 Shakespeare St, Nottingham NG1 4FQ, England
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- Wallis, Helen (author)
- Nottingham Trent Univ, 50 Shakespeare St, Nottingham NG1 4FQ, England
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- Chang, Ming-Wei (author)
- Univ Ulster, Nanotechnol & Integrated Bioengn Ctr, Jordanstown Campus, Newtownabbey BT37 0QB, North Ireland
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- Ahmad, Zeeshan (author)
- De Montfort Univ, Leicester LE1 9BH, Leics, England
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- Scholey, Dawn (author)
- Nottingham Trent Univ, 50 Shakespeare St, Nottingham NG1 4FQ, England
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- Burton, Emily (author)
- Nottingham Trent Univ, 50 Shakespeare St, Nottingham NG1 4FQ, England
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- Williams, Ian H. (author)
- Univ Bath, Dept Chem, Bath BA1 7AY, Avon, England
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- Kamerlin, Caroline Lynn, 1981- (author)
- Uppsala universitet,Biokemi
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- Wilson, Philippe B. (author)
- Nottingham Trent Univ, 50 Shakespeare St, Nottingham NG1 4FQ, England
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(creator_code:org_t)
- 2020
- 2020
- English.
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In: RSC Advances. - : Royal Society of Chemistry (RSC). - 2046-2069. ; 10:60, s. 36337-36348
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Abstract
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- The G-protein coupled receptors (GPCRs) superfamily comprise similar proteins arranged into families or classes thus making it one of the largest in the mammalian genome. GPCRs take part in many vital physiological functions making them targets for numerous novel drugs. GPCRs share some distinctive features, such as the seven transmembrane domains, they also differ in the number of conserved residues in their transmembrane domain. Here we provide an introductory and accessible review detailing the computational advances in GPCR pharmacology and drug discovery. An overview is provided on family A-C GPCRs; their structural differences, GPCR signalling, allosteric binding and cooperativity. The dielectric constant (relative permittivity) of proteins is also discussed in the context of site-specific environmental effects.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
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- By the author/editor
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Odoemelam, Chiem ...
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Percival, Benita
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Wallis, Helen
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Chang, Ming-Wei
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Ahmad, Zeeshan
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Scholey, Dawn
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show more...
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Burton, Emily
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Williams, Ian H.
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Kamerlin, Caroli ...
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Wilson, Philippe ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmacology and ...
- Articles in the publication
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RSC Advances
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Uppsala University