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Overexpression of c...
Overexpression of chromatin remodeling and tyrosine kinase genes in iAMP21-positive acute lymphoblastic leukemia
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- Ivanov Öfverholm, I. (author)
- Karolinska Institutet
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- Zachariadis, V. (author)
- Karolinska Institutet
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- Taylan, F. (author)
- Karolinska Institutet
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- Marincevic-Zuniga, Yanara (author)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
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- Tran, A. N. (author)
- Karolinska Institutet
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- Saft, L. (author)
- Karolinska Institutet
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- Nilsson, D. (author)
- Karolinska Institutet
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- Syvänen, Ann-Christine, 1950- (author)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
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- Lönnerholm, G, 1941- (author)
- Uppsala universitet,Barnneurologi/Barnonkologi
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Harila-Saari, A. (author)
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- Nordenskjöld, M. (author)
- Karolinska Institutet
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- Heyman, M. (author)
- Karolinska Institutet
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Nordgren, A. (author)
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- Nordlund, Jessica (author)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
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- Barbany, G. (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2019-10-22
- 2020
- English.
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In: Leukemia and Lymphoma. - : Informa UK Limited. - 1042-8194 .- 1029-2403. ; 61:3, s. 604-613
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Abstract
Subject headings
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- Intrachromosomal amplification of chromosome 21 (iAMP21) is a cytogenetic subtype associated with relapse and poor prognosis in pediatric B-cell precursor acute lymphoblastic leukemia (BCP ALL). The biology behind the high relapse risk is unknown and the aim of this study was to further characterize the genomic and transcriptional landscape of iAMP21. Using DNA arrays and sequencing, we could identify rearrangements and aberrations characteristic for iAMP21. RNA sequencing revealed that only half of the genes in the minimal region of amplification (20/45) were differentially expressed in iAMP21. Among them were the top overexpressed genes (p < 0.001) in iAMP21 vs. BCP ALL without iAMP21 and three candidate genes could be identified, the tyrosine kinase gene DYRK1A and chromatin remodeling genes CHAF1B and SON. While overexpression of DYRK1A and CHAF1B is associated with poor prognosis in malignant diseases including myeloid leukemia, this is the first study to show significant correlation with iAMP21-positive ALL.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- *Acute lymphoblastic leukemia
- *mp-wgs
- *gene expression analysis
- *iAMP21
- *transcriptome sequencing
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ivanov Öfverholm ...
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Zachariadis, V.
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Taylan, F.
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Marincevic-Zunig ...
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Tran, A. N.
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Saft, L.
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Nilsson, D.
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Syvänen, Ann-Chr ...
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Lönnerholm, G, 1 ...
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Harila-Saari, A.
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Nordenskjöld, M.
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Heyman, M.
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Nordgren, A.
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Nordlund, Jessic ...
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Barbany, G.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Leukemia and Lym ...
- By the university
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Uppsala University
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Karolinska Institutet