Intake and metabolism of omega-3 and omega-6 polyunsaturated fatty acids: nutritional implications for cardiometabolic diseases

Intake and metabolism of omega-3 and omega-6 polyunsaturated fatty acids : nutritional implications for cardiometabolic diseases

Schulze, Matthias B. (author): German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, D-14558 Nuthetal, Germany; Univ Potsdam, Inst Nutr Sci, Nuthetal, Germany; German Ctr Diabet Res, Neuherberg, Germany

Minihane, Anne Marie (author): Univ East Anglia, Dept Nutr & Prevent Med, Norwich Med Sch, Norwich, Norfolk, England

Saleh, Rasha Noureldin M. (author): Univ East Anglia, Dept Nutr & Prevent Med, Norwich Med Sch, Norwich, Norfolk, England; Alexandria Univ, Fac Med, Clin Pathol Dept, Alexandria, Egypt

Risérus, Ulf, 1967- (author): Uppsala universitet,Klinisk nutrition och metabolism

(creator_code:org_t)

2020
2020
English.
In: The Lancet Diabetes and Endocrinology. - 2213-8587 .- 2213-8595. ; 8:11, s. 915-930

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; show less...

Abstract Subject headings

Prospective observational studies support the use of long-chain omega-3 polyunsaturated fatty acids (PUFAs) in the primary prevention of atherosclerotic cardiovascular disease; however, randomised controlled trials, have often reported neutral findings. There is a long history of debate about the potential harmful effects of a high intake of omega-6 PUFAs, although this idea is not supported by prospective observational studies or randomised controlled trials. Health effects of PUFAs might be influenced by Δ-5 and Δ-6 desaturases, the key enzymes in the metabolism of PUFAs. The activity of these enzymes and modulation by variants in encoding genes (FADS1-2-3 gene cluster) are linked to several cardiometabolic traits. This Review will further consider non-genetic determinants of desaturase activity, which have the potential to modify the availability of PUFAs to tissues. Finally, we discuss the consequences of altered desaturase activity in the context of PUFA intake, that is, gene-diet interactions and their clinical and public health implications.

By the author/editor: Schulze, Matthia ...; Minihane, Anne M ...; Saleh, Rasha Nou ...; Risérus, Ulf, 19 ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Nutrition and Di ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.