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Outcomes of rituxim...
Outcomes of rituximab‐BEAM versus BEAM conditioning regimen in patients with diffuse large B cell lymphoma undergoing autologous transplantation
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- Jagadeesh, Deepa (author)
- Cleveland Clin Fdn, 9500 Euclid Ave, Cleveland, OH 44195 USA.
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- Majhail, Navneet S. (author)
- Cleveland Clin, Taussig Canc Inst, Blood & Marrow Transplant Program, Cleveland, OH 44106 USA.
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- He, Yizeng (author)
- Med Coll Wisconsin, Div Biostat, Inst Hlth & Equ, Milwaukee, WI 53226 USA.
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- Ahn, Kwang W. (author)
- Med Coll Wisconsin, Div Biostat, Inst Hlth & Equ, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA.
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- Litovich, Carlos (author)
- Med Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA.
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- Ahmed, Sairah (author)
- Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
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- Aljurf, Mahmoud (author)
- King Faisal Specialist Hosp Ctr & Res, Dept Oncol, Riyadh, Saudi Arabia.
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- Bacher, Ulrike (author)
- Univ Bern, Bern Univ Hosp, Inselspital, Dept Hematol, Bern, Switzerland.
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- Badawy, Sherif M. (author)
- Ann & Robert H Lurie Childrens Hosp Chicago, Div Hematol Oncol & Stem Cell Transplant, Chicago, IL 60611 USA.;Northwestern Univ, Dept Pediat, Feinberg Sch Med, Chicago, IL 60611 USA.
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- Bejanyan, Nelli (author)
- H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Tampa, FL USA.
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- Cairo, Mitchell (author)
- New York Med Coll, Dept Pediat, Div Pediat Hematol Oncol & Stem Cell Transplantat, Valhalla, NY 10595 USA.;Ohio State Univ, Dept Med, James Canc Hosp, Div Hematol, Columbus, OH 43210 USA.
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- Cerny, Jan (author)
- Univ Massachusetts, Med Ctr, Dept Med, Div Hematol Oncol, Worcester, MA USA.
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- Epperla, Narendranath (author)
- Ohio State Univ, Solove Res Inst, Columbus, OH 43210 USA.
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- Farhadfar, Nosha (author)
- Univ Florida, Coll Med, Div Hematol Oncol, Gainesville, FL USA.
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- Freytes, Cesar O. (author)
- Texas Transplant Inst, San Antonio, TX USA.
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- Gale, Robert Peter (author)
- Imperial Coll London, Dept Med, Div Expt Med, Hematol Res Ctr, London, England.
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- Haverkos, Bradley (author)
- Univ Colorado Hosp, Aurora, CO USA.
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- Hossain, Nasheed (author)
- Loyola Univ, Chicago Stritch Sch Med, Dept Med, Stem Cell Transplant Program,Div Hematol Oncol, Maywood, IL 60153 USA.
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- Inwards, David (author)
- Mayo Clin, Div Hematol, Rochester, MN USA.
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- Kamble, Rammurti T. (author)
- Baylor Coll Med, Div Hematol & Oncol, Ctr Cell & Gene Therapy, Houston, TX 77030 USA.
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- Kenkre, Vaishalee P. (author)
- Univ Wisconsin, Div Hematol Oncol, Madison, WI USA.
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- Lazarus, Hillard M. (author)
- Case Western Reserve Univ, Div Hematol Oncol, Cleveland, OH 44106 USA.
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- Lazaryan, Aleksandr (author)
- H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Tampa, FL USA.
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- Lekakis, Lazaros (author)
- Univ Miami, Dept Hematol Oncol, Miami, FL USA.
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- Mei, Matthew (author)
- City Hope Natl Med Ctr, Dept Hematol & Hematopoiet Cell Transplantat, Duarte, CA USA.
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- Murthy, Hemant S. (author)
- Mayo Clin Florida, Div Hematol Oncol, Blood & Marrow Transplantat Program, Jacksonville, FL USA.
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- Mussetti, Alberto (author)
- Inst Catala Oncol Hosp, Dept Hematol, Barcelona, Spain.;IDIBELL Inst Catala Oncol, Lhospitalet De Llobregat, El Prat De Llob, Spain.
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- Nathan, Sunita (author)
- Rush Univ, Div Hematol Oncol & Cell Therapy, Med Ctr, Chicago, IL 60612 USA.
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- Nishihori, Taiga (author)
- H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Tampa, FL USA.
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- Olsson, Richard (author)
- Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm, Sweden.
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- Geethakumari, Praveen Ramakrishnan (author)
- Univ Texas Southwestern Med Ctr, Lymphoma BMT & Cellular Therapy Program, Dallas, TX USA.
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- Savani, Bipin N. (author)
- Vanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA.
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- Yared, Jean A. (author)
- Univ Maryland, Dept Med, Blood & Marrow Transplantat Program, Greenebaum Comprehens Canc Ctr,Div Hematol Oncol, Baltimore, MD 21201 USA.
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- Fenske, Timothy S. (author)
- Med Coll Wisconsin, Dept Med, Div Hematol & Oncol, Milwaukee, WI 53226 USA.
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- Kharfan-Dabaja, Mohamed A. (author)
- Mayo Clin Florida, Div Hematol Oncol, Blood & Marrow Transplantat Program, Jacksonville, FL USA.
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- Sureda, Anna (author)
- Inst Catala Oncol Hosp, Dept Hematol, Barcelona, Spain.;IDIBELL Inst Catala Oncol, Lhospitalet De Llobregat, El Prat De Llob, Spain.
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- Hamadani, Mehdi (author)
- Med Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA.
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Cleveland Clin Fdn, 9500 Euclid Ave, Cleveland, OH 44195 USA Cleveland Clin, Taussig Canc Inst, Blood & Marrow Transplant Program, Cleveland, OH 44106 USA. (creator_code:org_t)
- 2020-02-12
- 2020
- English.
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In: Cancer. - : WILEY. - 0008-543X .- 1097-0142. ; 126:10, s. 2279-2287
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND Although rituximab-based high-dose therapy is frequently used in diffuse large B cell lymphoma (DLBCL) patients undergoing autologous hematopoietic cell transplantation (auto-HCT), data supporting the benefits are not available. Herein, we report the impact of rituximab-based conditioning on auto-HCT outcomes in patients who have DLBCL. METHODS Using the Center for International Blood and Marrow Transplant Research (CIBMTR) registry, 862 adult DLBCL patients undergoing auto-HCT between 2003 and 2017 using BEAM (BCNU, etoposide, cytarabine, melphalan) conditioning regimen were included. All patients received frontline rituximab-containing chemoimmunotherapy and had chemosensitive disease pre-HCT. Early chemoimmunotherapy failure was defined as not achieving complete remission (CR) after frontline chemoimmunotherapy or relapse within 1 year of initial diagnosis. The primary outcome was overall survival (OS). RESULTS The study cohort was divided into 2 groups: BEAM (n = 667) and R-BEAM (n = 195). On multivariate analysis, no significant difference was seen in OS (P = .83) or progression-free survival (PFS) (P = .61) across the 2 cohorts. No significant association between the use of rituximab and risk of relapse (P = .15) or nonrelapse mortality (P = .12) was observed. Variables independently associated with lower OS included older age at auto-HCT (P < .001), absence of CR at auto-HCT (P < .001) and early chemoimmunotherapy failure (P < .001). Older age (P < .0002) and non-CR pre-HCT (P < .0001) were also associated with inferior PFS. There was no significant difference in early infectious complications between the 2 cohorts. CONCLUSION In this large registry analysis of DLBCL patients undergoing auto-HCT, the addition of rituximab to the BEAM conditioning regimen had no impact on transplantation outcomes. Older age, absence of CR pre auto-HCT, and early chemoimmunotherapy failure were associated with inferior survival.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- autologous transplantation
- BEAM
- chemoimmunotherapy
- diffuse large B cell lymphoma
- rituximab
Publication and Content Type
- ref (subject category)
- art (subject category)
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Cancer
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- By the author/editor
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Jagadeesh, Deepa
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Majhail, Navneet ...
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He, Yizeng
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Ahn, Kwang W.
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Litovich, Carlos
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Ahmed, Sairah
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show more...
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Aljurf, Mahmoud
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Bacher, Ulrike
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Badawy, Sherif M ...
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Bejanyan, Nelli
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Cairo, Mitchell
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Cerny, Jan
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Epperla, Narendr ...
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Farhadfar, Nosha
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Freytes, Cesar O ...
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Gale, Robert Pet ...
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Haverkos, Bradle ...
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Hossain, Nasheed
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Inwards, David
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Kamble, Rammurti ...
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Kenkre, Vaishale ...
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Lazarus, Hillard ...
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Lazaryan, Aleksa ...
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Lekakis, Lazaros
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Mei, Matthew
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Murthy, Hemant S ...
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Mussetti, Albert ...
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Nathan, Sunita
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Nishihori, Taiga
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Olsson, Richard
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Geethakumari, Pr ...
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Savani, Bipin N.
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Yared, Jean A.
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Fenske, Timothy ...
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Kharfan-Dabaja, ...
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Sureda, Anna
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Hamadani, Mehdi
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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Cancer
- By the university
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Uppsala University
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Karolinska Institutet