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Prognostic implicat...
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Menter, ThomasUniv Hosp Basel, Inst Pathol & Med Genet, Basel, Switzerland.
(author)
Prognostic implications of the microenvironment for follicular lymphoma under immunomodulation therapy
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-02-03
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WILEY,2020
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-425118
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-425118URI
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https://doi.org/10.1111/bjh.16414DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-168139URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:142860270URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Follicular lymphoma (FL) constitutes a significant proportion of lymphomas and shows frequent relapses. Beyond conventional chemotherapy, new therapeutic approaches have emerged, focussing on the interplay between lymphoma cells and the microenvironment. Here we report the immunophenotypic investigation of the microenvironment of a clinically well-characterized prospective cohort (study SAKK35/10, NCT00544219) of 154 treatment-naive FL patients in need of therapy, who have been treated with rituximab only or a combination of rituximab and the immunomodulatory drug lenalidomide/Revlimid (R) A high ratio of CD4- to CD8-positive T cells (P = 0 center dot 009) and increased amounts of PD1(+) tumour-infiltrating T cells (P = 0 center dot 007) were associated with inferior progression-free survival in the whole cohort. Interestingly, the prognostic impact of PD1(+) T cells and the CD4/CD8 ratio lost its significance in the subgroup treated with R-2. In the latter group, high amounts of GATA3(+) T helper (Th2) equivalents were associated with better progression-free survival (P < 0 center dot 001). We identified tumour microenvironmental features that allow prognostic stratification with respect to immuno- and combined immuno- and immunomodulatory therapy. Our analysis indicates that lenalidomide may compensate the adverse prognostic implication of higher amounts of CD4(+) and, particularly, PD1(+) T cells and that it has favourable effects mainly in cases with higher amounts of Th2 equivalents.
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Tzankov, AlexandarUniv Hosp Basel, Inst Pathol & Med Genet, Basel, Switzerland.
(author)
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Zucca, EmanueleOncol Inst Southern Switzerland, Div Med Oncol, Bellinzona, Switzerland.;Inst Oncol Res, Bellinzona, Switzerland.;Bern Univ Hosp, Dept Med Oncol, Inselspital, Bern, Switzerland.
(author)
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Kimby, EvaKarolinska Institutet
(author)
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Hultdin, MagnusUmeå universitet,Patologi,Umeå Univ, Dept Med Biosci, Pathol, Umeå, Sweden.(Swepub:umu)magn0001
(author)
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Sundström, ChristerUppsala universitet,Experimentell och klinisk onkologi,Rose-Marie Amini(Swepub:uu)chrisund
(author)
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Beiske, KlausOslo Univ Hosp, Dept Pathol, Oslo, Norway.;Univ Oslo, Med Fac, Inst Clin Med, Oslo, Norway.
(author)
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Cogliatti, SergioCantonal Hosp, Inst Pathol, St Gallen, Switzerland.
(author)
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Banz, YaraUniv Bern, Inst Pathol, Bern, Switzerland.
(author)
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Cathomas, GieriKantonsspital Baselland, Inst Pathol, Liestal, Switzerland.
(author)
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Katjalainen-Lindsberg, Marja-LiisaHelsinki Univ Hosp, HUSLAB, Helsinki, Finland.
(author)
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Grobholz, RainerCantonal Hosp Aarau, Inst Pathol, Aarau, Switzerland.
(author)
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Mazzucchelli, LucaInst Pathol, Locarno, Switzerland.
(author)
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Sander, BirgittaKarolinska Institutet
(author)
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Hawle, HanneSAKK Coordinating Ctr, Bern, Switzerland.
(author)
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Hayoz, StefanieSAKK Coordinating Ctr, Bern, Switzerland.
(author)
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Dirnhofer, StefanUniv Hosp Basel, Inst Pathol & Med Genet, Basel, Switzerland.
(author)
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Univ Hosp Basel, Inst Pathol & Med Genet, Basel, Switzerland.Oncol Inst Southern Switzerland, Div Med Oncol, Bellinzona, Switzerland.;Inst Oncol Res, Bellinzona, Switzerland.;Bern Univ Hosp, Dept Med Oncol, Inselspital, Bern, Switzerland.
(creator_code:org_t)
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In:British Journal of Haematology: WILEY189:4, s. 707-7170007-10481365-2141
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Menter, Thomas
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Tzankov, Alexand ...
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Zucca, Emanuele
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Kimby, Eva
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Hultdin, Magnus
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Sundström, Chris ...
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Beiske, Klaus
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Cogliatti, Sergi ...
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Banz, Yara
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Cathomas, Gieri
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Katjalainen-Lind ...
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Grobholz, Rainer
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Mazzucchelli, Lu ...
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Sander, Birgitta
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Hawle, Hanne
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Hayoz, Stefanie
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Dirnhofer, Stefa ...
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