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Sökning: onr:"swepub:oai:DiVA.org:uu-425490" > Blocking endothelia...

Blocking endothelial apoptosis revascularizes the retina in a model of ischemic retinopathy

Grant, Zoe L. (författare)
Walter & Eliza Hall Inst Med Res, Parkville, Vic, Australia.;Univ Melbourne, Dept Med Biol, Parkville, Vic, Australia.
Whitehead, Lachlan (författare)
Walter & Eliza Hall Inst Med Res, Parkville, Vic, Australia.;Univ Melbourne, Dept Med Biol, Parkville, Vic, Australia.
Wong, Vickie H. Y. (författare)
Univ Melbourne, Dept Optometry & Vis Sci, Parkville, Vic, Australia.
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He, Zheng (författare)
Univ Melbourne, Dept Optometry & Vis Sci, Parkville, Vic, Australia.
Yan, Richard Y. (författare)
Walter & Eliza Hall Inst Med Res, Parkville, Vic, Australia.
Miles, Abigail R. (författare)
Walter & Eliza Hall Inst Med Res, Parkville, Vic, Australia.
Benest, Andrew, V (författare)
Univ Nottingham, Ctr Canc Sci, Sch Med, Div Canc & Stem Cells,Biodiscovery Inst, Nottingham, England.;Univ Birmingham, Ctr Membrane Prot & Receptors COMPARE, Birmingham, W Midlands, England.;Univ Nottingham, Birmingham, W Midlands, England.
Bates, David O. (författare)
Univ Nottingham, Ctr Canc Sci, Sch Med, Div Canc & Stem Cells,Biodiscovery Inst, Nottingham, England.;Univ Birmingham, Ctr Membrane Prot & Receptors COMPARE, Birmingham, W Midlands, England.;Univ Nottingham, Birmingham, W Midlands, England.
Prahst, Claudia (författare)
Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Vasc Biol Res, Boston, MA 02115 USA.
Bentley, Katie (författare)
Uppsala universitet,Vaskulärbiologi,Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Vasc Biol Res, Boston, MA 02115 USA.;Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA.
Bui, Bang, V (författare)
Univ Melbourne, Dept Optometry & Vis Sci, Parkville, Vic, Australia.
Symons, Robert C. A. (författare)
Univ Melbourne, Dept Optometry & Vis Sci, Parkville, Vic, Australia.;Univ Melbourne, Dept Surg, Parkville, Vic, Australia.;Royal Melbourne Hosp, Dept Ophthalmol, Parkville, Vic, Australia.
Coultas, Leigh (författare)
Walter & Eliza Hall Inst Med Res, Parkville, Vic, Australia.;Univ Melbourne, Dept Med Biol, Parkville, Vic, Australia.
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Walter & Eliza Hall Inst Med Res, Parkville, Vic, Australia;Univ Melbourne, Dept Med Biol, Parkville, Vic, Australia. Univ Melbourne, Dept Optometry & Vis Sci, Parkville, Vic, Australia. (creator_code:org_t)
AMER SOC CLINICAL INVESTIGATION INC, 2020
2020
Engelska.
Ingår i: Journal of Clinical Investigation. - : AMER SOC CLINICAL INVESTIGATION INC. - 0021-9738 .- 1558-8238. ; 130:8, s. 4235-4251
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Aberrant, neovascular retinal blood vessel growth is a vision-threatening complication in ischemic retinal diseases. It is driven by retinal hypoxia frequently caused by capillary nonperfusion and endothelial cell (EC) loss. We investigated the role of EC apoptosis in this process using a mouse model of ischemic retinopathy, in which vessel closure and EC apoptosis cause capillary regression and retinal ischemia followed by neovascularization. Protecting ECs from apoptosis in this model did not prevent capillary closure or retinal ischemia. Nonetheless, it prevented the clearance of ECs from closed capillaries, delaying vessel regression and allowing ECs to persist in clusters throughout the ischemic zone. In response to hypoxia, these preserved ECs underwent a vessel sprouting response and rapidly reassembled into a functional vascular network. This alleviated retinal hypoxia, preventing subsequent pathogenic neovascularization. Vessel reassembly was not limited by VEGFA neutralization, suggesting it was not dependent on the excess VEGFA produced by the ischemic retina. Neutralization of ANG2 did not prevent vessel reassembly, but did impair subsequent angiogenic expansion of the reassembled vessels. Blockade of EC apoptosis may promote ischemic tissue revascularization by preserving ECs within ischemic tissue that retain the capacity to reassemble a functional network and rapidly restore blood supply.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

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