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Unraveling the beha...
Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique : History, methodology and applications
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- Augustijns, Patrick (author)
- Katholieke Univ Leuven, Dept Pharmaceut & Pharmacol Sci, Drug Delivery & Disposit, Herestr 49,Box 921, B-3000 Leuven, Belgium.
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- Vertzoni, Maria (author)
- Natl & Kapodistrian Univ Athens, Sch Hlth Sci, Dept Pharm, Athens, Greece.
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- Reppas, Christos (author)
- Natl & Kapodistrian Univ Athens, Sch Hlth Sci, Dept Pharm, Athens, Greece.
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- Langguth, Peter (author)
- Johannes Gutenberg Univ Mainz, Inst Pharmaceut & Biomed Sci, D-55131 Mainz, Germany.
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- Lennernäs, Hans (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Abrahamsson, Bertil (author)
- AstraZeneca Gothenburg, Operat, Oral Prod Dev Pharmaceut Technol & Dev, S-43183 Molndal, Sweden.
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- Hasler, William L. (author)
- Univ Michigan, Dept Internal Med, Div Gastroenterol, Ann Arbor, MI 48109 USA.
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- Baker, Jason R. (author)
- Univ Michigan, Dept Internal Med, Div Gastroenterol, Ann Arbor, MI 48109 USA.
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- Vanuytsel, Tim (author)
- Katholieke Univ Leuven, Translat Res Ctr Gastrointestinal Disorders TARGI, Leuven, Belgium.
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- Tack, Jan (author)
- Katholieke Univ Leuven, Translat Res Ctr Gastrointestinal Disorders TARGI, Leuven, Belgium.
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- Corsetti, Maura (author)
- Nottingham Univ Hosp NHS Trust, NIHR Nottingham Biomed Res Ctr BRC, Nottingham, England.;Univ Nottingham, Nottingham, England.;Univ Nottingham, Nottingham Digest Dis Ctr, Sch Med, Nottingham, England.
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- Bermejo, Marival (author)
- Miguel Hernandez Univ, Dept Engn Pharm Sect, Alicante 03550, Spain.
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- Paixao, Paulo (author)
- Univ Lisbon, Fac Pharm, Res Inst Med iMed ULisboa, Av Prof Gama Pinto, P-1649003 Lisbon, Portugal.
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- Amidon, Gordon L. (author)
- Univ Michigan, Coll Pharm, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA.
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- Hens, Bart (author)
- Katholieke Univ Leuven, Dept Pharmaceut & Pharmacol Sci, Drug Delivery & Disposit, Herestr 49,Box 921, B-3000 Leuven, Belgium.
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Katholieke Univ Leuven, Dept Pharmaceut & Pharmacol Sci, Drug Delivery & Disposit, Herestr 49,Box 921, B-3000 Leuven, Belgium Natl & Kapodistrian Univ Athens, Sch Hlth Sci, Dept Pharm, Athens, Greece. (creator_code:org_t)
- ELSEVIER, 2020
- 2020
- English.
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In: European Journal of Pharmaceutical Sciences. - : ELSEVIER. - 0928-0987 .- 1879-0720. ; 155
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Abstract
Subject headings
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- Fluid sampling from the gastrointestinal (GI) tract has been applied as a valuable tool to gain more insight into the fluids present in the human GI tract and to explore the dynamic interplay of drug release, dissolution, precipitation and absorption after drug product administration to healthy subjects. In the last twenty years, collaborative initiatives have led to a plethora of clinical aspiration studies that aimed to unravel the luminal drug behavior of an orally administered drug product. The obtained drug concentration-time profiles from different segments in the GI tract were a valuable source of information to optimize and/or validate predictive in vitro and in silico tools, frequently applied in the non-clinical stage of drug product development. Sampling techniques are presently not only being considered as a stand-alone technique but are also used in combination with other in vivo techniques (e.g., gastric motility recording, magnetic resonance imaging (MRI)). By doing so, various physiological variables can be mapped simultaneously and evaluated for their impact on luminal drug and formulation behavior. This comprehensive review aims to describe the history, challenges and opportunities of the aspiration technique with a specific focus on how this technique can unravel the luminal behavior of drug products inside the human GI tract by providing a summary of studies performed over the last 20 years. A section `Best practices' on how to perform the studies and how to treat the aspirated samples is described. In the conclusion, we focus on future perspectives concerning this technique.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- Gastrointestinal drug concentrations
- Intestinal absorption
- Intraluminal drug and formulation behavior
- Sampling technique
- Aspiration studies
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Augustijns, Patr ...
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Vertzoni, Maria
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Reppas, Christos
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Langguth, Peter
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Lennernäs, Hans
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Abrahamsson, Ber ...
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show more...
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Hasler, William ...
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Baker, Jason R.
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Vanuytsel, Tim
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Tack, Jan
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Corsetti, Maura
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Bermejo, Marival
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Paixao, Paulo
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Amidon, Gordon L ...
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Hens, Bart
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmaceutical S ...
- Articles in the publication
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European Journal ...
- By the university
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Uppsala University