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Tumour Growth Rate ...
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Dromain, Clarisse
(author)
Tumour Growth Rate to predict the outcome of patients with Neuroendocrine Tumours : Performance and sources of variability
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2020-07-27
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S. Karger,2021
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-426099
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-426099URI
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https://doi.org/10.1159/000510445DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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INTRODUCTION: Tumor growth rate (TGR), percentage of change in tumor volume/month, has been previously identified as an early radiological biomarker for treatment monitoring in neuroendocrine tumors (NETs) patients. We assessed the performance and reproducibility of TGR 3 months (TGR3m) as a predictor factor of progression-free survival (PFS), including the impact of imaging method and reader variability.METHODS: Baseline and 3-months (±1month) CT/MRI images from patients with advanced, grade 1-2 NETs were retrospectively reviewed by 2 readers. Influence of number of targets, tumor burden and location of lesion on the performance of TGR3m to predict PFS was assessed by uni/multivariable Cox regression analysis. Agreement between readers was assessed by the Lin's concordance coefficient (LCC) and Kappa (KC).RESULTS: A total of 790 lesions were measured in 222 patients. Median PFS was 22.9 months. On univariable analysis, number of lesions (DISCUSSION/CONCLUSION: TGR3m is a robust and early radiological biomarker able to predict PFS. It may be used to identify patients with advanced NETs who require closer radiological follow-up.
Subject headings and genre
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Sundin, Anders,1954-Uppsala universitet,Radiologi(Swepub:uu)anderssu
(author)
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Najran, Pavan
(author)
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Vidal Trueba, Hector
(author)
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Dioguardi Burgio, Marco
(author)
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Crona, JoakimUppsala universitet,Endokrin tumörbiologi(Swepub:uu)joacr310
(author)
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Opalinska, Marta
(author)
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Carvalho, Luciana
(author)
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Franca, Regis
(author)
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Borg, Philip
(author)
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Vietti Violi, Naik
(author)
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Schaefer, Niklaus
(author)
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Lopez, Carlos
(author)
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Pezzutti, Daniela
(author)
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de Mestier, Louis
(author)
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Lamarca, Angela
(author)
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Costa, Frederico
(author)
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Pavel, Marianne
(author)
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Ronot, Maxime
(author)
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Uppsala universitetRadiologi
(creator_code:org_t)
Related titles
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In:Neuroendocrinology: S. Karger111:9, s. 831-8390028-38351423-0194
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Dromain, Clariss ...
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Sundin, Anders, ...
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Najran, Pavan
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Vidal Trueba, He ...
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Dioguardi Burgio ...
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Crona, Joakim
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Opalinska, Marta
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Carvalho, Lucian ...
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Franca, Regis
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Borg, Philip
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Vietti Violi, Na ...
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Schaefer, Niklau ...
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Lopez, Carlos
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Pezzutti, Daniel ...
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de Mestier, Loui ...
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Lamarca, Angela
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Costa, Frederico
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Pavel, Marianne
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Ronot, Maxime
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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Neuroendocrinolo ...
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Uppsala University