Search: onr:"swepub:oai:DiVA.org:uu-426108" >
Effect of PET-CT mi...
Effect of PET-CT misalignment on the quantitative accuracy of cardiac 15O-water PET
-
- Nordström, Jonny (author)
- Uppsala universitet,Radiologi,Centrum för klinisk forskning, Gävleborg,PET Centre, Uppsala University Hospital
-
- Harms, Hendrik J. (author)
- Uppsala universitet,Radiologi,Aarhus University Hospital; MedTrace Pharma A/S
-
- Kero, Tanja (author)
- Uppsala universitet,Radiologi,Medical Imaging Centre, Uppsala University Hospital
-
show more...
-
- Ebrahimi, Maryam (author)
- Uppsala universitet,Radiologi,Aarhus University Hospital
-
- Sörensen, Jens (author)
- Uppsala universitet,Radiologi,Aarhus University Hospital; Medical Imaging Centre, Uppsala University Hospital; MedTrace Pharma A/S
-
- Lubberink, Mark (author)
- Uppsala universitet,Radiologi,Medical Physics, Uppsala University Hospital; Aarhus University Hospital; MedTrace Pharma A/S
-
show less...
-
(creator_code:org_t)
- 2020-11-04
- 2022
- English.
-
In: Journal of Nuclear Cardiology. - : Springer Science and Business Media LLC. - 1071-3581 .- 1532-6551. ; 29:3, s. 1119-1128
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://uu.diva-port... (primary) (Raw object)
-
https://link.springe...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- BACKGROUND: Quantification of myocardial blood flow (MBF) with PET requires accurate attenuation correction, which is performed using a separate CT. Misalignment between PET and CT scans has been reported to be a common problem. The purpose of the present study was to assess the effect of PET CT misalignment on the quantitative accuracy of cardiac 15O-water PET.METHODS: Ten clinical patients referred for evaluation of ischemia and assessment of MBF with 15O-water were included in the study. Eleven different misalignments between PET and CT were induced in 6 different directions with 10 and 20 mm amplitudes: caudal (+Z), cranial (- Z), lateral (±X), anterior (+Y), and anterior combined with cranial (+ Y and - Z). Blood flow was quantified from rates of washout (MBF) and uptake (transmural MBF, MBFt) for the whole left ventricle and the three coronary territories. The results from all misalignments were compared to the original scan without misalignment.RESULTS: MBF was only minorly affected by misalignments, but larger effects were seen in MBFt. On the global level, average absolute deviation across all misalignments for MBF was 1.7% ± 1.4% and for MBFt 5.4% ± 3.2 Largest deviation for MBF was - 4.8% ± 5.8% (LCX, X + 20) and for MBFt - 19.3% ± 9.6% (LCX, X + 20). In general, larger effects were seen in LAD and LCX compared to in RCA.CONCLUSION: The quantitative accuracy of MBF from 15O-water PET, based on the washout of the tracer, is only to a minor extent affected by misalignment between PET and CT.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- PET
- image analysis
- myocardial blood flow
- perfusion agents
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database