Effect of PET-CT misalignment on the quantitative accuracy of cardiac 15O-water PET

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Nordström, JonnyUppsala universitet,Radiologi,Centrum för klinisk forskning, Gävleborg,PET Centre, Uppsala University Hospital (author)

Effect of PET-CT misalignment on the quantitative accuracy of cardiac 15O-water PET

Article/chapterEnglish2022

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2020-11-04
Springer Science and Business Media LLC,2022
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-426108
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-426108URI
https://doi.org/10.1007/s12350-020-02408-6DOI

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Language:English
Summary in:English

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BACKGROUND: Quantification of myocardial blood flow (MBF) with PET requires accurate attenuation correction, which is performed using a separate CT. Misalignment between PET and CT scans has been reported to be a common problem. The purpose of the present study was to assess the effect of PET CT misalignment on the quantitative accuracy of cardiac 15O-water PET.METHODS: Ten clinical patients referred for evaluation of ischemia and assessment of MBF with 15O-water were included in the study. Eleven different misalignments between PET and CT were induced in 6 different directions with 10 and 20 mm amplitudes: caudal (+Z), cranial (- Z), lateral (±X), anterior (+Y), and anterior combined with cranial (+ Y and - Z). Blood flow was quantified from rates of washout (MBF) and uptake (transmural MBF, MBFt) for the whole left ventricle and the three coronary territories. The results from all misalignments were compared to the original scan without misalignment.RESULTS: MBF was only minorly affected by misalignments, but larger effects were seen in MBFt. On the global level, average absolute deviation across all misalignments for MBF was 1.7% ± 1.4% and for MBFt 5.4% ± 3.2 Largest deviation for MBF was - 4.8% ± 5.8% (LCX, X + 20) and for MBFt - 19.3% ± 9.6% (LCX, X + 20). In general, larger effects were seen in LAD and LCX compared to in RCA.CONCLUSION: The quantitative accuracy of MBF from 15O-water PET, based on the washout of the tracer, is only to a minor extent affected by misalignment between PET and CT.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Radiologi och bildbehandling hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Radiology, Nuclear Medicine and Medical Imaging hsv//eng
PET
image analysis
myocardial blood flow
perfusion agents

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Harms, Hendrik J.Uppsala universitet,Radiologi,Aarhus University Hospital; MedTrace Pharma A/S(Swepub:uu)henha488 (author)
Kero, TanjaUppsala universitet,Radiologi,Medical Imaging Centre, Uppsala University Hospital(Swepub:uu)tanke311 (author)
Ebrahimi, MaryamUppsala universitet,Radiologi,Aarhus University Hospital (author)
Sörensen, JensUppsala universitet,Radiologi,Aarhus University Hospital; Medical Imaging Centre, Uppsala University Hospital; MedTrace Pharma A/S(Swepub:uu)jenssore (author)
Lubberink, MarkUppsala universitet,Radiologi,Medical Physics, Uppsala University Hospital; Aarhus University Hospital; MedTrace Pharma A/S(Swepub:uu)marklubb (author)
Uppsala universitetRadiologi (creator_code:org_t)

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In:Journal of Nuclear Cardiology: Springer Science and Business Media LLC29:3, s. 1119-11281071-35811532-6551

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