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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00009597naa a2200961 4500
001oai:DiVA.org:uu-426812
003SwePub
008201202s2020 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:145123578
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4268122 URI
0247 a https://doi.org/10.1038/s41586-020-2876-62 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1451235782 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Genereux, Diane P.u Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.4 aut
2451 0a A comparative genomics multitool for scientific discovery and conservation
264 c 2020-11-11
264 1b NATURE RESEARCH,c 2020
338 a electronic2 rdacarrier
500 a Group Authors: Zoonomia Consortium
520 a A whole-genome alignment of 240 phylogenetically diverse species of eutherian mammal-including 131 previously uncharacterized species-from the Zoonomia Project provides data that support biological discovery, medical research and conservation. The Zoonomia Project is investigating the genomics of shared and specialized traits in eutherian mammals. Here we provide genome assemblies for 131 species, of which all but 9 are previously uncharacterized, and describe a whole-genome alignment of 240 species of considerable phylogenetic diversity, comprising representatives from more than 80% of mammalian families. We find that regions of reduced genetic diversity are more abundant in species at a high risk of extinction, discern signals of evolutionary selection at high resolution and provide insights from individual reference genomes. By prioritizing phylogenetic diversity and making data available quickly and without restriction, the Zoonomia Project aims to support biological discovery, medical research and the conservation of biodiversity.
650 7a NATURVETENSKAPx Biologix Genetik0 (SwePub)106092 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Genetics0 (SwePub)106092 hsv//eng
650 7a NATURVETENSKAPx Biologix Evolutionsbiologi0 (SwePub)106152 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Evolutionary Biology0 (SwePub)106152 hsv//eng
7001 a Serres, Aitoru PRBB, Inst Evolutionary Biol UPF CSIC, Barcelona, Spain.4 aut
7001 a Armstrong, Joelu Univ Calif Santa Cruz, UC Santa Cruz Genom Inst, Santa Cruz, CA 95064 USA.4 aut
7001 a Johnson, Jeremyu Karolinska Institutet4 aut
7001 a Marinescu, Voichitau Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi4 aut0 (Swepub:uu)voima415
7001 a Murén, Evau Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)evmur020
7001 a Juan, Davidu PRBB, Inst Evolutionary Biol UPF CSIC, Barcelona, Spain.4 aut
7001 a Bejerano, Gillu Stanford Univ, Dept Biomed Data Sci, Stanford, CA 94305 USA.;Stanford Univ, Dept Comp Sci, Stanford, CA 94305 USA.;Stanford Univ, Dept Dev Biol, Stanford, CA 94305 USA.;Stanford Univ, Dept Pediat, Stanford, CA 94305 USA.4 aut
7001 a Casewell, Nicholas R.u Univ Liverpool Liverpool Sch Trop Med, Ctr Snakebite Res & Intervent, Liverpool, Merseyside, England.4 aut
7001 a Chemnick, Leona G.u Beckman Ctr Conservat Res, San Diego Zoo Global, San Diego, CA USA.4 aut
7001 a Damas, Joanau Univ Calif Davis, UC Davis Genome Ctr, Davis, CA 95616 USA.4 aut
7001 a Di Palma, Federicau Univ East Anglia, Dept Biol Sci, Norwich, Norfolk, England.;Earlham Inst, Norwich, Norfolk, England.4 aut
7001 a Diekhans, Marku Univ Calif Santa Cruz, UC Santa Cruz Genom Inst, Santa Cruz, CA 95064 USA.4 aut
7001 a Fiddes, Ian T.u Univ Calif Santa Cruz, UC Santa Cruz Genom Inst, Santa Cruz, CA 95064 USA.4 aut
7001 a Garber, Manuelu Univ Massachusetts, Sch Med, Program Bioinformat & Integrat Biol, Worcester, MA 01605 USA.4 aut
7001 a Gladyshev, Vadim N.u Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA.4 aut
7001 a Goodman, Lindau Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Stanford Univ, Dept Biomed Data Sci, Stanford, CA 94305 USA.;Fauna Bio Inc, Emeryville, CA USA.4 aut
7001 a Haerty, Wilfriedu Earlham Inst, Norwich, Norfolk, England.4 aut
7001 a Houck, Marlys L.u Beckman Ctr Conservat Res, San Diego Zoo Global, San Diego, CA USA.4 aut
7001 a Hubley, Robertu Inst Syst Biol, Seattle, WA USA.4 aut
7001 a Kivioja, Teemuu Univ Cambridge, Dept Biochem, Cambridge, England.;Univ Helsinki, Appl Tumor Genom Res Program, Helsinki, Finland.4 aut
7001 a Koepfli, Klaus-Peteru Smithsonian Mason Sch Conservat, Front Royal, VA USA.4 aut
7001 a Kuderna, Lukas F. K.u PRBB, Inst Evolutionary Biol UPF CSIC, Barcelona, Spain.4 aut
7001 a Lander, Eric S.u Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;MIT, Dept Biol, Cambridge, MA USA.;Harvard Med Sch, Dept Syst Biol, Boston, MA 02115 USA.4 aut
7001 a Meadows, Jenniferu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)jenme818
7001 a Murphy, William J.u Texas A&M Univ, Vet Integrat Biosci, College Stn, TX USA.4 aut
7001 a Nash, Willu Earlham Inst, Norwich, Norfolk, England.4 aut
7001 a Noh, Hyun Jiu Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.4 aut
7001 a Nweeia, Martinu Smithsonian Inst, Marine Mammal Program, Washington, DC 20560 USA.;Harvard Sch Dent Med, Restorat Dent & Biomat Sci, Boston, MA USA.;Case Western Reserve Univ, Sch Dent Med, Cleveland, OH 44106 USA.4 aut
7001 a Pfenning, Andreas R.u Carnegie Mellon Univ, Sch Comp Sci, Dept Computat Biol, Pittsburgh, PA 15213 USA.4 aut
7001 a Pollard, Katherine S.u Chan Zuckerberg Biohub, San Francisco, CA USA.;Gladstone Inst, San Francisco, CA USA.;Univ Calif San Francisco, Dept Epidemiol & Biostat, Inst Computat Hlth Sci, San Francisco, CA 94143 USA.;Univ Calif San Francisco, Inst Human Genet, San Francisco, CA 94143 USA.4 aut
7001 a Ray, David A.u Texas Tech Univ, Dept Sci Biol, Lubbock, TX 79409 USA.4 aut
7001 a Shapiro, Bethu Univ Calif Santa Cruz, Dept Ecol & Evolutionary Biol, Santa Cruz, CA 95064 USA.;Univ Calif Santa Cruz, Howard Hughes Med Inst, Santa Cruz, CA 95064 USA.4 aut
7001 a Smit, Arian F. A.u Inst Syst Biol, Seattle, WA USA.4 aut
7001 a Springer, Mark S.u Univ Calif Riverside, Dept Evolut Ecol & Organismal Biol, Riverside, CA 92521 USA.4 aut
7001 a Steiner, Cynthia C.u Beckman Ctr Conservat Res, San Diego Zoo Global, San Diego, CA USA.4 aut
7001 a Swofford, Rossu Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.4 aut
7001 a Taipale, Jussiu Univ Cambridge, Dept Biochem, Cambridge, England.;Univ Helsinki, Appl Tumor Genom Res Program, Helsinki, Finland.;Karolinska Inst, Dept Med Biochem & Biophys, Stockholm, Sweden.4 aut
7001 a Teeling, Emma C.u Univ Coll Dublin, Sch Biol & Environm Sci, Dublin, Ireland.4 aut
7001 a Turner-Maier, Jasonu Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.4 aut
7001 a Alfoldi, Jessicau Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.4 aut
7001 a Birren, Bruceu Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.4 aut
7001 a Ryder, Oliver A.u Beckman Ctr Conservat Res, San Diego Zoo Global, San Diego, CA USA.;Univ Calif San Diego, Div Biol, Dept Evolut Behav & Ecol, San Diego, CA 92103 USA.4 aut
7001 a Lewin, Harris A.u Univ Calif Davis, UC Davis Genome Ctr, Davis, CA 95616 USA.;Univ Calif Davis, Dept Evolut & Ecol, Davis, CA 95616 USA.4 aut
7001 a Paten, Benedictu Univ Calif Santa Cruz, UC Santa Cruz Genom Inst, Santa Cruz, CA 95064 USA.4 aut
7001 a Marques-Bonet, Tomasu PRBB, Inst Evolutionary Biol UPF CSIC, Barcelona, Spain.;Catalan Inst Res & Adv Studies ICREA, Barcelona, Spain.;Univ Autonoma Barcelona, Inst Catala Paleontol Miquel Crusafont, Barcelona, Spain.;Barcelona Inst Sci & Technol BIST, Ctr Genom Regulat CRG, CNAG CRG, Barcelona, Spain.4 aut
7001 a Lindblad-Toh, Kerstinu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Broad Inst MIT & Harvard, Cambridge, MA 02142 USA4 aut0 (Swepub:uu)kerli865
7001 a Karlsson, Elinor K.u Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Univ Massachusetts, Sch Med, Program Bioinformat & Integrat Biol, Worcester, MA 01605 USA.;Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA.4 aut
7102 a Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.b PRBB, Inst Evolutionary Biol UPF CSIC, Barcelona, Spain.4 org
7730 t Natured : NATURE RESEARCHg 587:7833, s. 240-245q 587:7833<240-245x 0028-0836x 1476-4687
8564 u https://doi.org/10.1038/s41586-020-2876-6y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1505926/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://www.nature.com/articles/s41586-020-2876-6.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-426812
8564 8u https://doi.org/10.1038/s41586-020-2876-6
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:145123578

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