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Vitamin D in Head a...
Vitamin D in Head and Neck Cancer : a Systematic Review
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- Makitie, Antti (author)
- Karolinska Institutet
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- Tuokkola, Iida (author)
- Univ Helsinki, Helsinki Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, POB 263, FI-00029 Helsinki, Finland.
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- Laurell, Göran (author)
- Uppsala universitet,Öron-, näs- och halssjukdomar
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- Makitie, Outi (author)
- Karolinska Institutet
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- Olsen, Kerry (author)
- Mayo Clin, Dept Otorhinolaryngol, Rochester, MN USA.
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- Takes, Robert P. (author)
- Radboud Univ Nijmegen, Med Ctr, Dept Otolaryngol Head & Neck Surg, Nijmegen, Netherlands.
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- Florek, Ewa (author)
- Poznan Univ Med Sci, Dept Toxicol, Lab Environm Res, Poznan, Poland.
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- Szyfter, Krzysztof (author)
- Polish Acad Sci, Inst Human Genet, Poznan, Poland.
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- Sier, Cornelis F. M. (author)
- Leiden Univ, Dept Surg, Med Ctr, Leiden, Netherlands.
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- Ferlito, Alfio (author)
- Int Head & Neck Sci Grp, Padua, Italy.
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Karolinska Institutet Univ Helsinki, Helsinki Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, POB 263, FI-00029 Helsinki, Finland (creator_code:org_t)
- 2020-11-20
- 2021
- English.
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In: Current Oncology Reports. - : Springer Nature. - 1523-3790 .- 1534-6269. ; 23:1
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Abstract
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- Purpose of review Observational studies have shown that serum 25-OH vitamin D [25(OH)D] is inversely associated with overall cancer risk in many malignancies. We performed a systematic literature review to determine whether vitamin D deficiency is related to head and neck cancer (HNC) etiology and outcome. Recent findings The search yielded five prospective studies reporting 25(OH)D levels prior to cancer diagnosis and their effect on the risk of HNC. Eight studies were cross-sectional or case-control studies, in which 25(OH)D levels were only measured after cancer diagnosis. Two studies found an inverse association between 25(OH)D level and HNC risk, while two other prospective cohort studies demonstrated no connection between 25(OH)D and HNC risk. Several studies reported cancer patients to have significantly lower 25(OH)D levels than controls. Associations between 25(OH)D and prognosis and mortality were variable. The link between vitamin D and HNC has so far only been investigated in a few observational, prospective, and case-control studies. Vitamin D deficiency may be more common in HNC patients than in the healthy population. There is no evidence for a causal relationship. Further studies are needed to evaluate whether low 25(OH)D concentrations play a role in the development or outcome of HNCs.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Carcinoma
- Etiology
- Deficiency
- Malignancy
- Surgery
- Radiotherapy
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- ref (subject category)
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- By the author/editor
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Makitie, Antti
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Tuokkola, Iida
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Laurell, Göran
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Makitie, Outi
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Olsen, Kerry
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Takes, Robert P.
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show more...
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Florek, Ewa
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Szyfter, Krzyszt ...
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Sier, Cornelis F ...
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Ferlito, Alfio
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Current Oncology ...
- By the university
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Uppsala University
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Karolinska Institutet