Generation of two human iPSC lines (UUIGPi013-A and UUIPGi014-A) from cases with Down syndrome and full trisomy for chromosome 21 (T21)

Schuster, Jens, Assistant Professor, 1972- (author): Uppsala universitet,Medicinsk genetik och genomik,Institutionen för cell- och molekylärbiologi,Science for Life Laboratory, SciLifeLab

Hoeber, Jan, 1986- (author): Uppsala universitet,Medicinsk genetik och genomik,Institutionen för neurovetenskap,Science for Life Laboratory, SciLifeLab

Sobol, Maria (author): Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik

Fatima, Ambrin (author): Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab

Annerén, Göran, 1945- (author): Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi

Dahl, Niklas (author): Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab,Barnkirurgisk forskning

(creator_code:org_t)

AMSTERDAM, NETHERLANDS : Elsevier BV, 2020
2020
English.
In: Stem Cell Research. - AMSTERDAM, NETHERLANDS : Elsevier BV. - 1873-5061 .- 1876-7753. ; 49

Related links:: https://doi.org/10.1...; show more...; https://doi.org/10.1...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Abstract Subject headings

Down syndrome (DS) is caused by trisomy for chromosome 21 (T21). We generated two induced pluripotent stem cell (iPSC) lines from skin fibroblasts of two males with DS using Sendai virus delivery of OCT4, SOX2, KLF4, and c-MYC. Characterization of the two iPSC lines, UUIGPi013-A and UUIPGi014-A, showed that they are genetically stable with a 47,XY,+21 karyotype. Both lines displayed expression of pluripotency markers and trilineage differentiation capacity. These two iPSC lines provide a useful resource for DS modeling and pharmacological interventions.

By the author/editor: Schuster, Jens, ...; Hoeber, Jan, 198 ...; Sobol, Maria; Fatima, Ambrin; Annerén, Göran, ...; Dahl, Niklas

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

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