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- Schuster, Jens,Assistant Professor,1972-Uppsala universitet,Medicinsk genetik och genomik,Institutionen för cell- och molekylärbiologi,Science for Life Laboratory, SciLifeLab (author)
Generation of two human iPSC lines (UUIGPi013-A and UUIPGi014-A) from cases with Down syndrome and full trisomy for chromosome 21 (T21)
- Article/chapterEnglish2020
Publisher, publication year, extent ...
- AMSTERDAM, NETHERLANDS :Elsevier BV,2020
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- LIBRIS-ID:oai:DiVA.org:uu-428382
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-428382URI
- https://doi.org/10.1016/j.scr.2020.102081DOI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- Down syndrome (DS) is caused by trisomy for chromosome 21 (T21). We generated two induced pluripotent stem cell (iPSC) lines from skin fibroblasts of two males with DS using Sendai virus delivery of OCT4, SOX2, KLF4, and c-MYC. Characterization of the two iPSC lines, UUIGPi013-A and UUIPGi014-A, showed that they are genetically stable with a 47,XY,+21 karyotype. Both lines displayed expression of pluripotency markers and trilineage differentiation capacity. These two iPSC lines provide a useful resource for DS modeling and pharmacological interventions.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
- Cell Biology; Biotechnology & Applied Microbiology
Added entries (persons, corporate bodies, meetings, titles ...)
- Hoeber, Jan,1986-Uppsala universitet,Medicinsk genetik och genomik,Institutionen för neurovetenskap,Science for Life Laboratory, SciLifeLab(Swepub:uu)janho717 (author)
- Sobol, MariaUppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik(Swepub:uu)marso197 (author)
- Fatima, AmbrinUppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab(Swepub:uu)fatam207 (author)
- Annerén, Göran,1945-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi(Swepub:uu)goraanne (author)
- Dahl, NiklasUppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab,Barnkirurgisk forskning(Swepub:uu)nikldahl (author)
- Uppsala universitetMedicinsk genetik och genomik (creator_code:org_t)
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- In:Stem Cell ResearchAMSTERDAM, NETHERLANDS : Elsevier BV491873-50611876-7753
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