Search: onr:"swepub:oai:DiVA.org:uu-429143" >
Colistin Resistance...
-
Dickstein, Yaakov
(author)
Colistin Resistance Development Following Colistin-Meropenem Combination Therapy Versus Colistin Monotherapy in Patients With Infections Caused by Carbapenem-Resistant Organisms
- Article/chapterEnglish2020
Publisher, publication year, extent ...
-
2019-11-23
-
Oxford University Press (OUP),2020
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:uu-429143
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-429143URI
-
https://doi.org/10.1093/cid/ciz1146DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
BACKGROUND: We evaluated whether carbapenem-colistin combination therapy given to patients with infections due to carbapenem-resistant Gram-negative organisms reduces the emergence of colistin resistance compared to colistin monotherapy.METHODS: This is a pre-planned analysis of a secondary outcome from a randomized controlled trial comparing colistin monotherapy with colistin-meropenem combination for the treatment of severe infections caused by carbapenem-resistant, colistin-susceptible Gram-negative bacteria. We evaluated rectal swabs taken on day 7 from enrollment or later for the presence of new colistin-resistant (ColR) isolates. We evaluated the emergence of any ColR isolate and the emergence of ColR Enterobacteriaceae (ColR-E).RESULTS: Data were available for 214 patients for the primary analysis; emergent ColR organisms were detected in 22 (10.3%). No difference was observed between patients randomized to treatment with colistin monotherapy (10/106, 9.4%) vs. patients randomized to colistin-meropenem combination therapy (12/108, 11.1%), p=0.669. ColR-E organisms were detected in 18/249 (7.2%) patients available for analysis. No difference was observed between the two treatment arms (colistin monotherapy 6/128 [4.7%] vs. combination therapy 12/121 [9.9%], p=0.111). Enterobacteriaceae as the index isolate was found to be associated with development of ColR-E (HR 3.875 95% CI 1.475-10.184, p=0.006).CONCLUSIONS: Carbapenem-colistin combination therapy did not reduce the incidence of colistin resistance emergence in patients with infections due to carbapenem-resistant organisms. Further studies are necessary to elucidate the development of colistin resistance and methods for its prevention.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Lellouche, Jonathan
(author)
-
Schwartz, David
(author)
-
Nutman, Amir
(author)
-
Rakovitsky, Nadya
(author)
-
Dishon Benattar, Yael
(author)
-
Altunin, Sergey
(author)
-
Bernardo, Mariano
(author)
-
Iossa, Domenico
(author)
-
Durante-Mangoni, Emanuele
(author)
-
Antoniadou, Anastasia
(author)
-
Skiada, Anna
(author)
-
Deliolanis, Ioannis
(author)
-
Daikos, George L
(author)
-
Daitch, Vered
(author)
-
Yahav, Dafna
(author)
-
Leibovici, Leonard
(author)
-
Rognås, ViktorUppsala universitet,Institutionen för farmaceutisk biovetenskap,Pharmacometrics(Swepub:uu)vikro885
(author)
-
Friberg, Lena E.Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Pharmacometrics(Swepub:uu)lenasimo
(author)
-
Mouton, Johan W
(author)
-
Paul, Mical
(author)
-
Carmeli, Yehuda
(author)
-
Uppsala universitetInstitutionen för farmaceutisk biovetenskap
(creator_code:org_t)
Related titles
-
In:Clinical Infectious Diseases: Oxford University Press (OUP)71:10, s. 2599-26071058-48381537-6591
Internet link
Find in a library
To the university's database
- By the author/editor
-
Dickstein, Yaako ...
-
Lellouche, Jonat ...
-
Schwartz, David
-
Nutman, Amir
-
Rakovitsky, Nady ...
-
Dishon Benattar, ...
-
show more...
-
Altunin, Sergey
-
Bernardo, Marian ...
-
Iossa, Domenico
-
Durante-Mangoni, ...
-
Antoniadou, Anas ...
-
Skiada, Anna
-
Deliolanis, Ioan ...
-
Daikos, George L
-
Daitch, Vered
-
Yahav, Dafna
-
Leibovici, Leona ...
-
Rognås, Viktor
-
Friberg, Lena E.
-
Mouton, Johan W
-
Paul, Mical
-
Carmeli, Yehuda
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Infectious Medic ...
- Articles in the publication
-
Clinical Infecti ...
- By the university
-
Uppsala University