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Patient preferences...
Patient preferences on rheumatoid arthritis second-line treatment : a discrete choice experiment of Swedish patients
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- Schölin Bywall, Karin (author)
- Uppsala universitet,Centrum för forsknings- och bioetik,Centre for Research Ethics & Bioethics, Department of Public Health and Caring Sciences, Uppsala University, Husargatan 3, Box 564, Uppsala, 752 37, Sweden
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- Kihlbom, Ulrik, 1961- (author)
- Uppsala universitet,Centrum för forsknings- och bioetik,Centre for Research Ethics & Bioethics, Department of Public Health and Caring Sciences, Uppsala University, Husargatan 3, Box 564, Uppsala, 752 37, Sweden
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- Hansson, Mats, 1952- (author)
- Uppsala universitet,Centrum för forsknings- och bioetik,Centre for Research Ethics & Bioethics, Department of Public Health and Caring Sciences, Uppsala University, Husargatan 3, Box 564, Uppsala, 752 37, Sweden
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- Falahee, Marie (author)
- Institute of Inflammation and Ageing, University of Birmingham Research Laboratories, Queen Elizabeth Hospital, Birmingham, B15 2WB, United Kingdom
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- Raza, Karim (author)
- Institute of Inflammation and Ageing, University of Birmingham Research Laboratories, Queen Elizabeth Hospital, Birmingham, B15 2WB, United Kingdom; Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, B18 7QH, United Kingdom
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- Baecklund, Eva, 1956- (author)
- Uppsala universitet,Reumatologi,Department of Medical Sciences, Rheumatology, Uppsala University, Uppsala, SE-751 85, Sweden
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- Veldwijk, Jorien (author)
- Erasmus School of Health Policy & Management, and Erasmus Choice Modelling Centre, Erasmus University Rotterdam, P.O. Box 1738, 3000, DR, Rotterdam, The Netherlands
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(creator_code:org_t)
- 2020-12-19
- 2020
- English.
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In: Arthritis Research & Therapy. - : Springer Science and Business Media LLC. - 1478-6362. ; 22
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Abstract
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- BackgroundPreference assessments of patients with rheumatoid arthritis can support clinical therapeutic decisions for including biologic and targeted synthetic medicines to use. This study assesses patient preferences for attributes of second-line therapies and heterogeneity within these preferences to estimate the relative importance of treatment characteristics and to calculate the minimum benefit levels patients require to accept higher levels of side effects.MethodsBetween November 2018 to August 2019, patients with rheumatoid arthritis were recruited to a survey containing demographic and disease-related questions as well as a discrete choice experiment to measure their preferences for second-line therapies using biologics or Janus kinases inhibitors. Treatment characteristics included were route of administration, frequency of use, probability of mild short-term side effects, probability of side effects changing appearance, probability of psychological side effects, probability of severe side effects and effectiveness of treatment.ResultsA total of 358 patients were included in the analysis. A latent class analysis revealed three preference patterns: (1) treatment effectiveness as the single most important attribute, (2) route of administration as the most important attribute, closely followed by frequency of use and psychological side effects and (3) severe side effects as the most important attribute followed by psychological side effects. In addition, disease duration and mild side effects influenced the patients’ choices.ConclusionRespondents found either effectiveness, route of administration or severe side effects as the most important attribute. Patients noting effectiveness as most important were more willing than other patients to accept higher risks of side effects.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Samhällsfarmaci och klinisk farmaci (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Social and Clinical Pharmacy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Discrete choice experiment
- Patient preferences
- Rheumatoid arthritis
- Second-line treatment
Publication and Content Type
- ref (subject category)
- art (subject category)
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Schölin Bywall, ...
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Kihlbom, Ulrik, ...
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Hansson, Mats, 1 ...
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Falahee, Marie
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Raza, Karim
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Baecklund, Eva, ...
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Veldwijk, Jorien
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Social and Clini ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
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Arthritis Resear ...
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Uppsala University
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Mälardalen University