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Reproducibility in ...
Reproducibility in the unfolding process of protein induced by an external electric field
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- Sinelnikova, Anna (author)
- Uppsala universitet,Materialteori
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- Mandl, Thomas (author)
- Uppsala universitet,Kemisk och biomolekylär fysik,University of Applied Sciences Technikum Wien, Höchstädtplatz 6, A-1200 Wien, Austria
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- Östlin, Christofer (author)
- Uppsala universitet,Materialteori
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- Grånäs, Oscar, 1979- (author)
- Uppsala universitet,Materialteori
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- Brodmerkel, Maxim N. (author)
- Uppsala universitet,Biokemi
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- Marklund, Erik, Teknologie doktor, 1979- (author)
- Uppsala universitet,Biokemi,Erik Marklund
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- Caleman, Carl (author)
- Uppsala universitet,Kemisk och biomolekylär fysik
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(creator_code:org_t)
- Royal Society of Chemistry, 2021
- 2021
- English.
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In: Chemical Science. - : Royal Society of Chemistry. - 2041-6520 .- 2041-6539. ; 12:6, s. 2030-2038
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Abstract
Subject headings
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- The dynamics of proteins are crucial for their function. However, commonly used techniques for studying protein structures are limited in monitoring time-resolved dynamics at high resolution. Combining electric fields with existing techniques to study gas phase proteins, such as Single Particle Imaging using Free-electron Lasers and gas phase Small Angle X-ray Scattering, has the potential to open up a new era in time-resolved studies of gas phase protein dynamics. Using molecular dynamics simulations, we identify well-defined unfolding pathways of a protein, induced by experimentally achievable external electric fields. Our simulations show that strong electric fields in conjunction with short pulsed X-ray sources such as Free-electron Lasers can be a new path for imaging dynamics of gas-phase proteins at high spatial and temporal resolution.
Subject headings
- NATURVETENSKAP -- Biologi -- Biofysik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biophysics (hsv//eng)
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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