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High prevalence of ...
High prevalence of undiagnosed comorbidities among adolescents with obesity
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- Leong, Karen S. W. (author)
- Univ Auckland, Liggins Inst, Auckland, New Zealand; Better Start Natl Sci Challenge, Auckland, New Zealand
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- Jayasinghe, Thilini N. (author)
- Univ Auckland, Liggins Inst, Auckland, New Zealand
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- Wilson, Brooke C. (author)
- Univ Auckland, Liggins Inst, Auckland, New Zealand
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- Derraik, José G. B. (author)
- Uppsala universitet,Perinatal, neonatal och barnkardiologisk forskning,Univ Auckland, Liggins Inst, Auckland, New Zealand; Better Start Natl Sci Challenge, Auckland, New Zealand; Zhejiang Univ, Childrens Hosp, Dept Endocrinol, Sch Med, Hangzhou, Peoples R China
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- Albert, Benjamin B. (author)
- Univ Auckland, Liggins Inst, Auckland, New Zealand; Better Start Natl Sci Challenge, Auckland, New Zealand
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- Chiavaroli, Valentina (author)
- Univ Auckland, Liggins Inst, Auckland, New Zealand; Pescara Publ Hosp, Neonatal Intens Care Unit, Pescara, Italy
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- Svirskis, Darren M. (author)
- Univ Auckland, Fac Med & Hlth Sci, Sch Pharm, Auckland, New Zealand
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- Beck, Kathryn L. (author)
- Massey Univ, Coll Hlth, Sch Sport Exercise & Nutr, Auckland, New Zealand
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- Conlon, Cathryn A. (author)
- Massey Univ, Coll Hlth, Sch Sport Exercise & Nutr, Auckland, New Zealand
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- Jiang, Yannan (author)
- Univ Auckland, Dept Stat, Auckland, New Zealand
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- Schierding, William (author)
- Univ Auckland, Liggins Inst, Auckland, New Zealand
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- Vatanen, Tommi (author)
- Univ Auckland, Liggins Inst, Auckland, New Zealand; Broad Inst MIT & Harvard, Cambridge, MA 02142 USA
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- Holland, David J. (author)
- Counties Manukau Dist Hlth Board, Dept Infect Dis, Auckland, New Zealand
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- O'Sullivan, Justin M. (author)
- Univ Auckland, Liggins Inst, Auckland, New Zealand; Better Start Natl Sci Challenge, Auckland, New Zealand
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- Cutfield, Wayne S. (author)
- Univ Auckland, Liggins Inst, Auckland, New Zealand; Better Start Natl Sci Challenge, Auckland, New Zealand; Zhejiang Univ, Childrens Hosp, Dept Endocrinol, Sch Med, Hangzhou, Peoples R China
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(creator_code:org_t)
- 2020-11-18
- 2020
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10:1
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Abstract
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- Metabolic diseases are increasing among adolescents with obesity. Although the reported prevalence of metabolic syndrome is approximately 30% worldwide, its prevalence is largely unknown among New Zealand adolescents. Therefore, we assessed the health of adolescents with obesity (BMI ≥ 30 kg/m2) enrolled in a randomised clinical trial (Gut Bugs Trial), to identify the prevalence of undiagnosed comorbidities. Assessments included anthropometry, 24-h ambulatory blood pressure monitoring, and insulin sensitivity. We report on baseline data (pre-randomisation) on 87 participants (14–18 years; 59% females), with mean BMI 36.9 ± 5.3 kg/m2 (BMI SDS 3.33 ± 0.79). Approximately 40% of participants had undiagnosed metabolic syndrome, which was twice as common among males. Half (53%) had pre-diabetes and 92% a reduction in insulin sensitivity. Moreover, 31% had pre-hypertension/hypertension, 69% dyslipidaemia, and 25% abnormal liver function. Participants with class III obesity had a greater risk of metabolic syndrome than those with classes I/II [relative risk 1.99 (95% CI 1.19, 3.34)]. Risks for pre-hypertension/hypertension and inflammation were also greater among those with class III obesity. We identified a high prevalence of undiagnosed comorbidities among adolescents with obesity in New Zealand. As adolescent obesity tracks into adulthood, early interventions are needed to prevent progression to overt cardiometabolic diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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Leong, Karen S. ...
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Jayasinghe, Thil ...
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Wilson, Brooke C ...
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Derraik, José G. ...
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Albert, Benjamin ...
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Chiavaroli, Vale ...
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show more...
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Svirskis, Darren ...
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Beck, Kathryn L.
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Conlon, Cathryn ...
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Jiang, Yannan
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Schierding, Will ...
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Vatanen, Tommi
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Holland, David J ...
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O'Sullivan, Just ...
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Cutfield, Wayne ...
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