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- Runow Stark, ChristinaUppsala universitet,Käkkirurgi,Folktandvården Stockholms län AB (author)
Brush Samples of Oral Lesions to FTA Elute Card for High-risk Human Papilloma Virus Diagnosis
- Article/chapterEnglish2021
Publisher, publication year, extent ...
- 2021-01-08
- Anticancer Research USA Inc.2021
- printrdacarrier
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- LIBRIS-ID:oai:DiVA.org:uu-430547
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-430547URI
- https://doi.org/10.21873/anticanres.14773DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:145775102URI
Supplementary language notes
- Language:English
- Summary in:English
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- AIM: To investigate the level of agreement between three non-invasive methods for hrHPV diagnosis in oral and oropharyngeal squamous cell carcinoma (OSCC, OPSCC) and in oral mucosal lesions.MATERIALS AND METHODS: For hrHPV DNA FTA Elute card™ and Anyplex II HPV28™ were used and for hrHPV mRNA PreTect SEE™ in tumour patients (n=60), non-tumour lesions (n=51), immunosuppression or previous hrHPV-infection (n=32).RESULTS: The level of agreement between the DNA-methods was 82.2% (k=0.54, p=0.001). Pair-wise comparison for the FTA Elute card were close to the reference (AUC=0.83, 95% CI=0.73-0.90). hrHPV mRNA was diagnosed in 50% of the tumours, with an agreement level of 58.3%, compared to Anyplex II (k=0.17, p=0.04). The hrHPV positivity in oral lesions was 3.9% for immunosuppression and for previous HPV infection 9.4%.CONCLUSION: The FTA card is reliable for hrHPV DNA diagnosis while mRNA gives an insight into viral activity and correlates with severity of the lesion.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Mikrobiologi inom det medicinska området hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Microbiology in the medical area hsv//eng
- DNA
- FTA Elute card
- hrHPV
- human papillomavirus
- mRNA
- oral- and oropharyngeal cancer
- potentially malignant oral disorders
- real-time PCR
Added entries (persons, corporate bodies, meetings, titles ...)
- Gustavsson, IngerUppsala universitet,Medicinsk genetik och genomik(Swepub:uu)ingergus (author)
- Horal, Peter (author)
- Kotopouli, MariaKarolinska Institutet (author)
- Gyllensten, UlfUppsala universitet,Medicinsk genetik och genomik(Swepub:uu)ulfgyll (author)
- Hirsch, Jan-MichaélUppsala universitet,Käkkirurgi,Folktandvården Stockholms län AB(Swepub:uu)jahir257 (author)
- Uppsala universitetKäkkirurgi (creator_code:org_t)
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- In:Anticancer Research: Anticancer Research USA Inc.41:1, s. 269-2770250-70051791-7530
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