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PD-L1 expression in gastroenteropancreatic neuroendocrine neoplasms grade 3
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- Ali, Abir Salwa, 1986- (author)
- Uppsala universitet,Onkologisk endokrinologi
- Langer, Seppo W. (author)
- Federspiel, Birgitte (author)
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- Hjortland, Geir Olav (author)
- Grønbæk, Henning (author)
- Ladekarl, Morten (author)
- Weber Vestermark, Lene (author)
- Arola, Johanna (author)
- Osterlund, Pia (author)
- Knigge, Ulrich (author)
- Sørbye, Halfdan (author)
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- (creator_code:org_t)
- 2020-12-14
- 2020
- English.
- In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 15:12
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Gastroenteropancreatic neuroendocrine neoplasms grade 3 (GEP-NENs G3) are rare tumors. These highly aggressive neoplasms are traditionally treated with platinum-based chemotherapy in combination with etoposide. Immune checkpoint proteins such as programmed cell death ligand (PD-L1) may have a role in different cancers allowing them escape the immune system and hence, progress. We aimed to investigate the immunohistochemical expression of PD-L1 in GEP-NEN G3 and evaluate its correlation to clinical parameters. In a cohort of 136 patients, 14 (10%) expressed PD-L1 immunoreactivity; four (3%) patients in the tumor cells and 10 (7%) had immunoreactive immune cells. PD-L1 expression did not correlate to clinical parameters, progression-free survival or overall survival. We conclude that PD-L1 expression is present only in a subset of GEP-NEN G3 patients. Further studies are needed to fully understand the role of PD-L1 in patients with GEP-NEN G3, including the future possibility for treatment with immune checkpoint inhibitors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- Osterlund, Pia
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