Exhaled nitric oxide physiology and modeling

• Nitric oxide (NO) is involved in many processes in the respiratory system. Its detection in exhaled breath and the subsequent discovery of its flow dependency led to the development of a two-compartment model for NO in the respiratory system. Based on this model, alveolar NO and bronchial NO flux can be calculated by measuring fractional exhaled NO (FENO) at several high exhalation flows. If FENO is additionally measured at a very low flow, the airway wall NO concentration and diffusivity of NO that make up bronchial NO flux can be determined. In addition to facilitating research, these parameters may have clinical value in estimating airway inflammation and pathophysiological processes for several pulmonary diseases. Reference values and standardized mathematical methods to determine NO parameters have been established and are accepted for use of FENO in clinical practice.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)

Keyword

NO

FENO

Clinical Physiology

Klinisk fysiologi

Lungmedicin

Lung Medicine

Publication and Content Type

vet (subject category)

kap (subject category)