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High incidence but ...
High incidence but low mortality of EBV-reactivation and PTLD after alloHCT using ATG and PTCy for GVHD prophylaxis
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Queralt Salas, Maria (author)
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Prem, Shruti (author)
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- Remberger, Mats (author)
- Uppsala universitet,Hematologi
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Lam, Wilson (author)
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Dong Hwan Kim, Dennis (author)
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Michelis, Fotios Vasilios (author)
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Al-Shaibani, Zeyad (author)
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Gerbitz, Armin (author)
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Lipton, Jeffrey Howard (author)
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Viswabandya, Auro (author)
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Kumar, Rajat (author)
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Kumar, Deepali (author)
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- Mattsson, Jonas (author)
- Karolinska Institutet
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Datt Law, Arjun (author)
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(creator_code:org_t)
- 2020-07-25
- 2020
- English.
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In: Leukemia and Lymphoma. - : Informa UK Limited. - 1042-8194 .- 1029-2403. ; 61:13, s. 3198-3208
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- We explore risk factors and impacts of post-transplant EBV-Reactivation (EBV-R) and PTLD in 270 patients that underwent RIC alloHCT using ATG-PTCy and cyclosporine for GVHD prophylaxis. Twenty-five (12%) patients had probable (n = 7) or proven (n = 18) PTLD. Patients were managed with reduction of immunosuppression and 22 with weekly rituximab (375 mg/m2 IV). ORR was 84%; 8 (32%) recipients died, and one-year OS and NRM of patients with PTLD was 59.7% and 37%, respectively. One hundred seventy-two (63.7%) recipients had EBV-R. One-year OS and RFS of patients with EBV-R were 68.2% and 60.6%, and of EBV-Negative patients were 62.1% and 50.1%, respectively. High incidence but low mortality of EBV-R and PTLD was documented. EBV-R induced a protective effect on RFS in multivariable analysis (HR 0.91, p = .011). Therefore, EBV-R may have a protective effect on RFS in this setting. Further research is necessary to evaluate the interplay of EBV-R, immune reconstitution, and post-transplant outcomes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- Epstein-Barr Virus
- PTLD
- alloHCT
- reduced intensity conditioning
- ATG
- PTCy
- Klinisk immunologi
- Clinical Immunology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Queralt Salas, M ...
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Prem, Shruti
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Remberger, Mats
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Lam, Wilson
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Dong Hwan Kim, D ...
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Michelis, Fotios ...
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show more...
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Al-Shaibani, Zey ...
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Gerbitz, Armin
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Lipton, Jeffrey ...
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Viswabandya, Aur ...
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Kumar, Rajat
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Kumar, Deepali
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Mattsson, Jonas
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Datt Law, Arjun
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Leukemia and Lym ...
- By the university
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Uppsala University
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Karolinska Institutet