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Distinct developmen...
Distinct developmental pathways from blood monocytes generate human lung macrophage diversity
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- Evren, Elza (author)
- Karolinska Institutet
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Ringqvist, Emma (author)
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Tripathi, Kumar Parijat (author)
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Sleiers, Natalie (author)
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Rives, Inés Có (author)
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- Alisjahbana, Arlisa (author)
- Karolinska Institutet
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- Gao, Yu (author)
- Karolinska Institutet
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- Sarhan, Dhifaf (author)
- Karolinska Institutet
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- Halle, Tor (author)
- Uppsala universitet,Klinisk och experimentell patologi,Fredrik Pontén
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- Sorini, Chiara (author)
- Karolinska Institutet
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- Lepzien, Rico (author)
- Karolinska Institutet
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- Marquardt, Nicole (author)
- Karolinska Institutet
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- Michaëlsson, Jakob (author)
- Karolinska Institutet
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Smed-Sörensen, Anna (author)
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- Botling, Johan (author)
- Uppsala universitet,Klinisk och experimentell patologi,Johan Botling
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- Karlsson, Mikael C. I. (author)
- Karolinska Institutet
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Villablanca, Eduardo J. (author)
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- Willinger, Tim (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- English.
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In: Immunity. - : Elsevier. - 1074-7613 .- 1097-4180. ; 51, s. 35-35
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Abstract
Subject headings
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- The study of human macrophages and their ontogeny is an important unresolved issue. Here, we use a humanized mouse model expressing human cytokines to dissect the development of lung macrophages from human hematopoiesis in vivo. Human CD34+ hematopoietic stem and progenitor cells (HSPCs) generated three macrophage populations, occupying separate anatomical niches in the lung. Intravascular cell labeling, cell transplantation, and fate-mapping studies established that classical CD14+ blood monocytes derived from HSPCs migrated into lung tissue and gave rise to human interstitial and alveolar macrophages. In contrast, non-classical CD16+ blood monocytes preferentially generated macrophages resident in the lung vasculature (pulmonary intravascular macrophages). Finally, single-cell RNA sequencing defined intermediate differentiation stages in human lung macrophage development from blood monocytes. This study identifies distinct developmental pathways from circulating monocytes to lung macrophages and reveals how cellular origin contributes to human macrophage identity, diversity, and localization in vivo.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- blood monocytes
- fate mapping
- human macrophages
- humanized mice
- intravascular macrophages
- lung
- ontogeny
- origin
- single-cell RNA sequencing
- Pathology
- Patologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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Immunity
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To the university's database
- By the author/editor
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Evren, Elza
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Ringqvist, Emma
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Tripathi, Kumar ...
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Sleiers, Natalie
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Rives, Inés Có
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Alisjahbana, Arl ...
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show more...
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Gao, Yu
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Sarhan, Dhifaf
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Halle, Tor
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Sorini, Chiara
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Lepzien, Rico
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Marquardt, Nicol ...
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Michaëlsson, Jak ...
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Smed-Sörensen, A ...
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Botling, Johan
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Karlsson, Mikael ...
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Villablanca, Edu ...
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Willinger, Tim
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Clinical Laborat ...
- Articles in the publication
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Immunity
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EUROPEAN JOURNAL ...
- By the university
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Uppsala University
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Karolinska Institutet