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Pharmacokinetics of...
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Jacobs, Tom G.Radboud Univ Nijmegen, Radboud Inst Hlth Sci, Med Ctr, Dept Pharm, Nijmegen, Netherlands.
(author)
Pharmacokinetics of antiretroviral and tuberculosis drugs in children with HIV/TB co-infection : a systematic review
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-08-12
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Oxford University Press (OUP),2020
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electronicrdacarrier
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LIBRIS-ID:oai:DiVA.org:uu-431617
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-431617URI
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https://doi.org/10.1093/jac/dkaa328DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:for swepub-publicationtype
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Introduction: Management of concomitant use of ART and TB drugs is difficult because of the many drug-drug interactions (DDIs) between the medications. This systematic review provides an overview of the current state of knowledge about the pharmacokinetics (PK) of ART and TB treatment in children with HIV/TB co-infection, and identifies knowledge gaps. Methods: We searched Embase and PubMed, and systematically searched abstract books of relevant conferences, following PRISMA guidelines. Studies not reporting PK parameters, investigating medicines that are not available any Longer or not including children with HIV/TB co-infection were excluded. ALL studies were assessed for quality. Results: In total, 47 studies met the inclusion criteria. No dose adjustments are necessary for efavirenz during concomitant first-Line TB treatment use, but intersubject PK variability was high, especially in children <3 years of age. Super-boosted Lopinavir/ritonavir (ratio 1:1) resulted in adequate Lopinavir trough concentrations during rifampicin co-administration. Double-dosed raltegravir can be given with rifampicin in children >4 weeks old as well as twice-daily dolutegravir (instead of once daily) in children older than 6 years. Exposure to some TB drugs (ethambutol and rifampicin) was reduced in the setting of HIV infection, regardless of ART use. Only Limited PK data of second-Line TB drugs with ART in children who are HIV infected have been published. Conclusions: Whereas integrase inhibitors seem favourable in older children, there are Limited options for ART in young children (<3 years) receiving rifampicin-based TB therapy. The PK of TB drugs in HIV-infected children warrants further research.
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Svensson, Elin,1985-Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Radboud Univ Nijmegen, Radboud Inst Hlth Sci, Med Ctr, Dept Pharm, Nijmegen, Netherlands,Farmakometri(Swepub:uu)elisv718
(author)
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Musiime, VictorJoint Clin Res Ctr, Res Dept, Kampala, Uganda.;Makerere Univ, Coll Hlth Sci, Sch Med, Dept Paediat & Child Hlth, Kampala, Uganda.
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Rojo, PabloUniv Complutense, Hosp 12 Octubre, Fac Med, Pediat Infect Dis Unit, Madrid, Spain.
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Dooley, Kelly E.Johns Hopkins Univ, Sch Med, Dept Med, Div Clin Pharmacol, Baltimore, MD 21205 USA.;Johns Hopkins Univ, Sch Med, Dept Med, Div Infect Dis, Baltimore, MD 21205 USA.
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McIlleron, HelenUniv Cape Town, Dept Med, Div Clin Pharmacol, Cape Town, South Africa.
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Aarnoutse, Rob E.Radboud Univ Nijmegen, Radboud Inst Hlth Sci, Med Ctr, Dept Pharm, Nijmegen, Netherlands.
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Burger, David M.Radboud Univ Nijmegen, Radboud Inst Hlth Sci, Med Ctr, Dept Pharm, Nijmegen, Netherlands.
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Turkova, AnnaUCL, Inst Clin Trials & Methodol, MRC Clin Trials Unit UCL, London, England.
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Colbers, AngelaRadboud Univ Nijmegen, Radboud Inst Hlth Sci, Med Ctr, Dept Pharm, Nijmegen, Netherlands.
(author)
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Radboud Univ Nijmegen, Radboud Inst Hlth Sci, Med Ctr, Dept Pharm, Nijmegen, Netherlands.Institutionen för farmaceutisk biovetenskap
(creator_code:org_t)
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In:Journal of Antimicrobial Chemotherapy: Oxford University Press (OUP)75:12, s. 3433-34570305-74531460-2091
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Jacobs, Tom G.
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Musiime, Victor
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Rojo, Pablo
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Dooley, Kelly E.
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Burger, David M.
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Turkova, Anna
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