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Therapygenetic effe...
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Schiele, Miriam A.Univ Freiburg, Germany
(author)
Therapygenetic effects of 5-HTTLPR on cognitive-behavioral therapy in anxiety disorders : A meta-analysis
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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Elsevier,2021
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-432506
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-432506URI
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https://doi.org/10.1016/j.euroneuro.2021.01.004DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:146043631URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-174376URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-191902URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|German Research Foundation (DFG)German Research Foundation (DFG) [44541416 -TRR 58, SFB 1193 Z03]; German Ministry of Research and Education (BMBF, PROTECT-AD)Federal Ministry of Education & Research (BMBF) [01EE1402F]; UK Medical Research CouncilUK Research & Innovation (UKRI)Medical Research Council UK (MRC) [G0901874]; German Federal Ministry of Education and Research (BMBF) as part of the larger BMBF Psychotherapy Research Funding Initiative Improving the Treatment of Panic Disorder [01GV0614]
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This work was supported by the German Research Foundation (DFG) – Project No. 44541416 – TRR 58, projects C02 (to KD), C09 (to UL) and Z02 (to AR, KD, PP, TBL and UL), SFB 1193 Z03 (to AR), and the German Ministry of Research and Education (BMBF, 01EE1402F, PROTECT-AD, P5 to KD).This work was partly funded by a grant from the UK Medical Research Council to TC Eley (G0901874).The study is in part funded by the German Federal Ministry of Education and Research (BMBF, 01GV0614) as part of the larger BMBF Psychotherapy Research Funding Initiative Improving the Treatment of Panic Disorder.
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There is a recurring debate on the role of the serotonin transporter gene linked polymorphic region (5-HTTLPR) in the moderation of response to cognitive behavioral therapy (CBT) in anxiety disorders. Results, however, are still inconclusive. We here aim to perform a meta-analysis on the role of 5-HTTLPR in the moderation of CBT outcome in anxiety disorders. We investigated both categorical (symptom reduction of at least 50%) and dimensional outcomes from baseline to post-treatment and follow-up. Original data were obtained from ten independent samples (including three unpublished samples) with a total of 2,195 patients with primary anxiety disorder. No significant effects of 5-HTTLPR genotype on categorical or dimensional outcomes at post and follow-up were detected. We conclude that current evidence does not support the hypothesis of 5-HTTLPR as a moderator of treatment outcome for CBT in anxiety disorders. Future research should address whether other factors such as long-term changes or epigenetic processes may explain further variance in these complex gene-environment interactions and molecular-genetic pathways that may confer behavioral change following psychotherapy.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Reif, AndreasUniv Hosp Frankfurt, Germany
(author)
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Lin, JiaxiUniv Freiburg, Germany
(author)
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Alpers, Georg W.Univ Mannheim, Germany
(author)
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Andersson, EvelynKarolinska Institutet,Karolinska Inst, Sweden
(author)
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Andersson, Gerhard,Fil dr, Med dr,1966-Linköpings universitet,Karolinska Institutet,Psykologi,Filosofiska fakulteten(Swepub:liu)geran87
(author)
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Arolt, VolkerUniv Munster, Germany
(author)
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Bergström, JanStockholms universitet,Klinisk psykologi(Swepub:su)janb
(author)
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Carlbring, PerStockholms universitet,Klinisk psykologi(Swepub:su)pecar
(author)
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Eley, Thalia C.Kings Coll London, England
(author)
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Esquivel, GabrielMaastricht Univ, Netherlands
(author)
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Furmark, TomasUppsala universitet,Institutionen för psykologi,Uppsala Univ, Sweden(Swepub:uu)tomafurm
(author)
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Gerlach, Alexander L.Univ Cologne, Germany
(author)
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Hamm, AlfonsErnst Moritz Arndt Univ Greifswald, Germany
(author)
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Helbig-Lang, SylviaUniv Hamburg, Germany
(author)
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Hudson, Jennifer L.Macquarie Univ, Australia
(author)
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Lang, ThomasChristoph Dornier Fdn Clin Psychol, Germany; Jacobs Univ Bremen, Germany
(author)
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Lester, Kathryn J.Univ Sussex, England
(author)
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Lindefors, NilsKarolinska Institutet,Karolinska Inst, Sweden; Stockholm Hlth Care Serv, Sweden
(author)
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Lonsdorf, Tina B.Univ Med Ctr Hamburg Eppendorf, Germany
(author)
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Pauli, PaulJulius Maximilians Univ Wurzburg, Germany; Julius Maximilians Univ Wurzburg, Germany
(author)
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Richter, JanErnst Moritz Arndt Univ Greifswald, Germany,Maastricht Univ, Netherlands
(author)
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Rief, WinfriedPhilipps Univ Marburg, Germany
(author)
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Roberts, SusannaKings Coll London, England
(author)
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Rück, ChristianKarolinska Institutet,Karolinska Inst, Sweden; Stockholm Hlth Care Serv, Sweden
(author)
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Schruers, Koen R.J.
(author)
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Thiel, ChristianeUniv Freiburg, Germany
(author)
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Wittchen, Hans-UlrichTech Univ Dresden, Germany
(author)
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Domschke, KatharinaUniv Freiburg, Germany; Univ Freiburg, Germany
(author)
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Weber, HeikeUniv Hosp Frankfurt, Germany; Univ Hosp Wurzburg, Germany
(author)
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Lueken, UlrikeUniv Hosp Wurzburg, Germany; Humboldt Univ, Germany
(author)
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Univ Freiburg, GermanyUniv Hosp Frankfurt, Germany
(creator_code:org_t)
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In:European Neuropsychopharmacology: Elsevier44, s. 105-1200924-977X1873-7862
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Schiele, Miriam ...
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Reif, Andreas
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Lin, Jiaxi
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Alpers, Georg W.
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Andersson, Evely ...
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Andersson, Gerha ...
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Arolt, Volker
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Bergström, Jan
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Carlbring, Per
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Eley, Thalia C.
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Esquivel, Gabrie ...
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Furmark, Tomas
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Gerlach, Alexand ...
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Hamm, Alfons
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Helbig-Lang, Syl ...
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Hudson, Jennifer ...
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Lang, Thomas
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Lester, Kathryn ...
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Lindefors, Nils
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Lonsdorf, Tina B ...
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Pauli, Paul
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Richter, Jan
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Rief, Winfried
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Roberts, Susanna
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Rück, Christian
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Schruers, Koen R ...
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Thiel, Christian ...
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Wittchen, Hans-U ...
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Domschke, Kathar ...
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Weber, Heike
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Lueken, Ulrike
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