Search: onr:"swepub:oai:DiVA.org:uu-433908" > The Ion Channel and...
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000 | 04653naa a2200505 4500 | |
001 | oai:DiVA.org:uu-433908 | |
003 | SwePub | |
008 | 210203s2020 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:145569241 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4339082 URI |
024 | 7 | a https://doi.org/10.3389/fncel.2020.6013242 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1455692412 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a for2 swepub-publicationtype |
100 | 1 | a Hariharan, Ashwiniu Univ Maryland, Sch Med, Dept Physiol, Baltimore, MD 21201 USA.4 aut |
245 | 1 0 | a The Ion Channel and GPCR Toolkit of Brain Capillary Pericytes |
264 | c 2020-12-18 | |
264 | 1 | a LAUSANNE, SWITZERLAND :b Frontiers Media SA,c 2020 |
338 | a electronic2 rdacarrier | |
520 | a Brain pericytes reside on the abluminal surface of capillaries, and their processes cover similar to 90% of the length of the capillary bed. These cells were first described almost 150 years ago (Eberth, 1871; Rouget, 1873) and have been the subject of intense experimental scrutiny in recent years, but their physiological roles remain uncertain and little is known of the complement of signaling elements that they employ to carry out their functions. In this review, we synthesize functional data with single-cell RNAseq screens to explore the ion channel and G protein-coupled receptor (GPCR) toolkit of mesh and thin-strand pericytes of the brain, with the aim of providing a framework for deeper explorations of the molecular mechanisms that govern pericyte physiology. We argue that their complement of channels and receptors ideally positions capillary pericytes to play a central role in adapting blood flow to meet the challenge of satisfying neuronal energy requirements from deep within the capillary bed, by enabling dynamic regulation of their membrane potential to influence the electrical output of the cell. In particular, we outline how genetic and functional evidence suggest an important role for G(s)-coupled GPCRs and ATP-sensitive potassium (K-ATP) channels in this context. We put forth a predictive model for long-range hyperpolarizing electrical signaling from pericytes to upstream arterioles, and detail the TRP and Ca2+ channels and G(q), G(i/o), and G(12/13) signaling processes that counterbalance this. We underscore critical questions that need to be addressed to further advance our understanding of the signaling topology of capillary pericytes, and how this contributes to their physiological roles and their dysfunction in disease. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
653 | a pericytes | |
653 | a ion channels | |
653 | a GPCRs (G protein coupled receptors) | |
653 | a neurovascular coupling (NVC) | |
653 | a cerebral blood flow (CBF) | |
653 | a K-ATP channels | |
653 | a brain metabolism | |
700 | 1 | a Weir, Nicku Univ Maryland, Sch Med, Dept Physiol, Baltimore, MD 21201 USA.4 aut |
700 | 1 | a Robertson, Colinu Univ Maryland, Sch Med, Dept Physiol, Baltimore, MD 21201 USA.4 aut |
700 | 1 | a He, Liqunu Uppsala universitet,Vaskulärbiologi,Uppsala Univ, Dept Immunol Genet & Pathol, Rudbeck Lab, Uppsala, Sweden.4 aut0 (Swepub:uu)liqhe592 |
700 | 1 | a Betsholtz, Christeru Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Dept Immunol Genet & Pathol, Rudbeck Lab, Uppsala, Sweden.;Karolinska Inst, Dept Med Huddinge MedH, Huddinge, Sweden.;Integrated Cardio Metab Ctr, Huddinge, Sweden.4 aut0 (Swepub:uu)chbet517 |
700 | 1 | a Longden, Thomas A.u Univ Maryland, Sch Med, Dept Physiol, Baltimore, MD 21201 USA.4 aut |
710 | 2 | a Univ Maryland, Sch Med, Dept Physiol, Baltimore, MD 21201 USA.b Vaskulärbiologi4 org |
773 | 0 | t Frontiers in Cellular Neuroscienced LAUSANNE, SWITZERLAND : Frontiers Media SAg 14q 14x 1662-5102 |
856 | 4 | u https://doi.org/10.3389/fncel.2020.601324y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1525446/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://www.frontiersin.org/articles/10.3389/fncel.2020.601324/pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-433908 |
856 | 4 8 | u https://doi.org/10.3389/fncel.2020.601324 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:145569241 |
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